Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 11/20 | 0.39 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | NNMT | P40261 | 4/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15737300 | 0.87 | DHODH (0.44) | DHODHSYK | |
| SCHEMBL27855175 | 0.79 | CSF1R (0.51) | CSF1RSYK | |
| SCHEMBL4719793 | 0.79 | NNMT (0.54) | NNMTSYKCDK8CDK19 | |
| SCHEMBL26337674 | 0.75 | NNMT (0.42) | DHODHNNMTSYKCDK8CDK19 | |
| SCHEMBL29812246 | 0.73 | KMT2A (0.39) | CSF1RNNMTSYK | |
| SCHEMBL17467977 | 0.73 | SYK (0.39) | NNMTSYKCDK8CDK19 | |
| SCHEMBL17467968 | 0.71 | KMT2A (0.42) | CSF1RNNMTSYK | |
| SCHEMBL31696427 | 0.70 | KDM4E (0.41) | SYK | |
| SCHEMBL19117674 | 0.70 | P2RX3 (0.37) | NNMTSYK | |
| SCHEMBL2987993 | 0.69 | KMT2A (0.38) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9248122-B2 | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators | Grünenthal GmbH (DE) | 2016-02-02 | — | — | US | disclosed |