Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | NNMT | P40261 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ATF1 | P18846 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15736349 | 0.87 | PDE4B (0.41) | SYKGAAPDE4BNR1H2NR1H3 | |
| SCHEMBL2649173 | 0.74 | TAS2R14 (0.39) | SYKGAAPDE4BTGFBR1TRPV1 | |
| SCHEMBL17467966 | 0.73 | CSF1R (0.39) | SYKNNMTCDK8CDK19 | |
| SCHEMBL8568056 | 0.73 | KDM4E (0.49) | GAANR1H2NR1H3KMT2ALMNA | |
| SCHEMBL30572236 | 0.72 | LMNA (0.54) | GAANNMTLMNA | |
| SCHEMBL3550940 | 0.72 | LMNA (0.54) | GAANNMTLMNA | |
| SCHEMBL27855175 | 0.72 | CSF1R (0.51) | SYKPARP1KMT2A | |
| SCHEMBL8564446 | 0.72 | KMT2A (0.55) | KMT2ALMNAATF1NFKB1 | |
| SCHEMBL29207870 | 0.69 | SYK (0.41) | SYKGAAPDE4BPARP1KMT2A | |
| SCHEMBL30775503 | 0.69 | SYK (0.41) | SYKGAAPDE4BPARP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9248122-B2 | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators | Grünenthal GmbH (DE) | 2016-02-02 | — | — | US | disclosed |