Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.38 |
| ▸ | TUBB | P07437 | 4/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.38 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19317483 | 0.85 | DHODH (0.38) | HDAC6ALDH1A1METAP2KDM4EHPGD | |
| SCHEMBL17469274 | 0.81 | CYP3A4 (0.38) | MTNR1AMTNR1BHDAC6ALDH1A1KDM4E | |
| SCHEMBL17469279 | 0.81 | ENPP3 (0.38) | MTNR1AMTNR1BHDAC6TUBB4ATUBB | |
| SCHEMBL17469282 | 0.81 | NQO2 (0.45) | MTNR1AMTNR1BTUBB4ATUBBTUBA3C | |
| SCHEMBL17469285 | 0.81 | CFTR (0.41) | MTNR1AHDAC6TUBB4ATUBBTUBA3C | |
| SCHEMBL17469281 | 0.80 | BCHE (0.36) | MTNR1AHDAC6TUBB4ATUBBTUBA3C | |
| SCHEMBL17469275 | 0.80 | BCHE (0.36) | HDAC6TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19322129 | 0.78 | GAA (0.40) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL19322245 | 0.77 | KDM4E (0.40) | HDAC6TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL17469286 | 0.76 | BCHE (0.36) | MTNR1AMTNR1BALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11147795-B2 | Neuroprotective compounds and methods of use | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-10-19 | — | — | US | disclosed |
| US-20190350902-A1 | NEUROPROTECTIVE COMPOUNDS AND METHODS OF USE | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2019-11-21 | — | — | US | disclosed |
| US-10358438-B2 | [3+2] annulation to produce 5-membered heterocyclic compounds | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2019-07-23 | — | — | US | disclosed |
| US-20170253580-A1 | ORGANIC REACTIONS | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2017-09-07 | — | — | US | disclosed |
| WO-2016014426-A1 | ORGANIC REACTIONS | THE ARIZONA BOARD OF REGENTS (US) | 2016-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11147795-B2 | Neuroprotective compounds and methods of use | RTN3, CHRNB3, ARRB1 | MTNR1A 365/4885MTNR1B 741/4885HDAC6 611/4885 |
| US-20170253580-A1 | ORGANIC REACTIONS | MYC, CYP2E1, CYP3A4 | MTNR1A 3861/4885MTNR1B 3609/4885HDAC6 2895/4885 |
| US-20190350902-A1 | NEUROPROTECTIVE COMPOUNDS AND METHODS OF USE | RTN3, CHRNB3, ARRB1 | MTNR1A 365/4885MTNR1B 741/4885HDAC6 611/4885 |
| US-10358438-B2 | [3+2] annulation to produce 5-membered heterocyclic compounds | ACR, MYC, TOP1 | MTNR1A 4370/4885MTNR1B 3913/4885HDAC6 982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.