Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 9/20 | 0.42 |
| ▸ | F2 | P00734 | 5/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.41 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.41 |
| ▸ | F7 | P08709 | 2/20 | 0.41 |
| ▸ | F3 | P13726 | 2/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 2/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17469621 | 0.89 | F7 (0.43) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL17469624 | 0.79 | KIT (0.44) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL17469875 | 0.75 | FLT3 (0.41) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL17469769 | 0.69 | PLAU (0.41) | PRSS1F2EGFRKDRKLK1 | |
| SCHEMBL17469844 | 0.69 | FLT3 (0.42) | ST14F7F3 | |
| SCHEMBL17469772 | 0.68 | PLAU (0.49) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL17469662 | 0.67 | KIT (0.40) | F2EGFRKDRLMNASMN1; SMN2 | |
| SCHEMBL17469777 | 0.63 | KCNJ11 (0.44) | PRSS1F2KLK1 | |
| SCHEMBL3667557 | 0.63 | PRSS1 (0.72) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL10691567 | 0.63 | G6PD (0.48) | ACP1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016014674-A1 | LINKED DIARYL COMPOUNDS WITH ANTICANCER PROPERTIES AND METHODS OF USING THE SAME | UNIVERSITY OF MARYLAND, COLLEGE PARK (US) | 2016-01-28 | — | — | WO | disclosed |