Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.36 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17469621 | 0.87 | F7 (0.43) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL19006217 | 0.82 | FLT3 (0.61) | FLT3KITNTRK3EGFRF2 | |
| SCHEMBL17469845 | 0.75 | PRSS1 (0.42) | EGFRF2PRSS1PRSS2PRSS3 | |
| SCHEMBL17469662 | 0.72 | KIT (0.40) | FLT3KITNTRK3EGFRF2 | |
| SCHEMBL17469844 | 0.70 | FLT3 (0.42) | FLT3KITNTRK3ST14F7 | |
| SCHEMBL17469641 | 0.69 | KIT (0.47) | FLT3KITNTRK3F2 | |
| SCHEMBL17469656 | 0.67 | KIT (0.43) | FLT3KITNTRK3F2 | |
| SCHEMBL13283185 | 0.65 | HTT (0.68) | FLT3EGFR | |
| SCHEMBL17469874 | 0.65 | EGFR (0.53) | FLT3EGFR | |
| SCHEMBL20001656 | 0.63 | PRSS1 (0.66) | F2PRSS1PRSS2PRSS3TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016014674-A1 | LINKED DIARYL COMPOUNDS WITH ANTICANCER PROPERTIES AND METHODS OF USING THE SAME | UNIVERSITY OF MARYLAND, COLLEGE PARK (US) | 2016-01-28 | — | — | WO | disclosed |