Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | AGPAT2 | O15120 | 4/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.30 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17469641 | 0.85 | KIT (0.47) | KITFLT3NTRK3RAB9AF2 | |
| SCHEMBL17469656 | 0.82 | KIT (0.43) | KITFLT3NTRK3LMNASMN1; SMN2 | |
| SCHEMBL17469639 | 0.80 | KIT (0.67) | KITFLT3NTRK3NPC1RAB9A | |
| SCHEMBL17469875 | 0.72 | FLT3 (0.41) | KITFLT3NTRK3EGFRF2 | |
| SCHEMBL21153064 | 0.71 | KIT (0.56) | KITFLT3NTRK3NPC1RAB9A | |
| SCHEMBL17469797 | 0.69 | CCNC (0.45) | — | |
| SCHEMBL17469778 | 0.69 | KIT (0.70) | KITFLT3NTRK3NPC1RAB9A | |
| SCHEMBL17469845 | 0.67 | PRSS1 (0.42) | LMNASMN1; SMN2EGFRKDRF2 | |
| SCHEMBL26485348 | 0.66 | HDAC1 (0.43) | LMNASMN1; SMN2F2HDAC1HDAC2 | |
| SCHEMBL31249942 | 0.66 | HDAC3 (0.55) | NPC1RAB9ALMNAHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016014674-A1 | LINKED DIARYL COMPOUNDS WITH ANTICANCER PROPERTIES AND METHODS OF USING THE SAME | UNIVERSITY OF MARYLAND, COLLEGE PARK (US) | 2016-01-28 | — | — | WO | disclosed |