Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17472011 | 0.87 | CA12 (0.37) | CA12CA1CA9PSMB8MAP4K4 | |
| SCHEMBL1115122 | 0.86 | CA12 (0.47) | CA12CA1CA9PSMB8MAP4K4 | |
| SCHEMBL3006400 | 0.80 | IDO1 (0.45) | CA12CA1CA9PSMB8ACSS2 | |
| SCHEMBL17472012 | 0.80 | RAB9A (0.41) | CA12CA1CA9MAP4K4ALDH1A1 | |
| SCHEMBL19412998 | 0.76 | CA12 (0.39) | CA12CA1CA9PSMB8SIRT2 | |
| SCHEMBL14872698 | 0.74 | CA12 (0.38) | CA12CA1CA9PSMB8SIRT2 | |
| SCHEMBL12394685 | 0.71 | JAK2 (0.40) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL14464303 | 0.71 | CA12 (0.43) | CA12CA1CA9PSMB8MAP4K4 | |
| SCHEMBL1115135 | 0.69 | CA12 (0.47) | CA12CA1CA9PSMB8SIRT2 | |
| SCHEMBL31662956 | 0.69 | CA12 (0.47) | CA12CA1CA9MAP4K4ACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9381254-B2 | Methods for preparing polymeric reagents | NEKTAR THERAPEUTICS (US) | 2016-07-05 | — | — | US | disclosed |
| US-20160022830-A1 | METHODS FOR PREPARING POLYMERIC REAGENTS | NEKTAR THERAPEUTICS | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022830-A1 | METHODS FOR PREPARING POLYMERIC REAGENTS | PAM, ALKBH3, DNPEP | CA12 82/4885CA1 116/4885CA9 357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.