SCHEMBL1747384

SCHEMBL1747384

COC(=O)CCc1ccc(OCc2ccc(C=O)cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 7/20 0.56
FFAR4 Q5NUL3 3/20 0.51
ADRB2 P07550 1/20 0.50
ADRB1 P08588 1/20 0.50
RAB9A P51151 3/20 0.49
NPC1 O15118 2/20 0.49
TDP1 Q9NUW8 1/20 0.47
LTA4H P09960 1/20 0.46
ALDH1A1 P00352 1/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.46
HPGD P15428 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
VDR P11473 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL697461 0.88 CYP4F2 (0.50) ADRB2ADRB1ALDH1A1LMNAMAPT
SCHEMBL1747136 0.84 FFAR1 (0.72) FFAR1FFAR4RAB9ANPC1TDP1
SCHEMBL18269510 0.84 FFAR1 (0.72) FFAR1FFAR4TDP1LMNA
SCHEMBL1745247 0.84 FFAR1 (0.72) FFAR1FFAR4RAB9ANPC1TDP1
SCHEMBL15679198 0.84 FFAR1 (0.60) FFAR1FFAR4ADRB2ADRB1ALDH1A1
SCHEMBL14305720 0.83 FFAR1 (0.67) FFAR1FFAR4RAB9ANPC1TDP1
SCHEMBL1745397 0.83 FFAR1 (0.58) FFAR1FFAR4ADRB2ADRB1RAB9A
SCHEMBL1745363 0.83 FFAR1 (0.58) FFAR1FFAR4ADRB2ADRB1RAB9A
SCHEMBL4255258 0.83 MAOB (0.60) FFAR1FFAR4ADRB2ADRB1
SCHEMBL1745141 0.83 FFAR1 (0.58) FFAR1FFAR4ADRB2ADRB1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR FFAR1 33/4885FFAR4 44/4885ADRB2 316/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.