SCHEMBL1747427

SCHEMBL1747427

O=C1NC(Cc2ccc(OCc3cccc(Oc4ccccc4)c3)cc2)C(=O)S1

nearest known ligand 0.52

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 16/20 0.52
FFAR4 Q5NUL3 3/20 0.52
PPARA Q07869 1/20 0.47
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
KDM4C Q9H3R0 1/20 0.42
LTA4H P09960 1/20 0.40
PLA2G2A P14555 1/20 0.40
MMP1 P03956 1/20 0.40
HPGD P15428 1/20 0.40
PTPN1 P18031 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1746646 0.88 FFAR1 (0.63) FFAR1FFAR4PPARAMEN1KMT2A
SCHEMBL9326656 0.82 HRH3 (0.48) FFAR1PPARAMEN1KMT2AKDM4C
SCHEMBL1747426 0.78 FFAR1 (0.78) FFAR1FFAR4PPARA
SCHEMBL4940660 0.78 GAA (0.44)
SCHEMBL9491438 0.74 FFAR1 (0.68) FFAR1FFAR4
SCHEMBL377642 0.73 CYP3A4 (0.46) MEN1KMT2AHPGDPTPN1
SCHEMBL7455599 0.72 PPARD (0.44) FFAR1PPARAMEN1KMT2AHPGD
SCHEMBL21840806 0.72 HRH3 (0.60) FFAR1FFAR4MEN1KMT2AKDM4C
SCHEMBL30438225 0.72 HRH3 (0.60) FFAR1FFAR4MEN1KMT2AKDM4C
SCHEMBL9803869 0.72 FFAR1 (0.42) FFAR1PPARAMEN1KMT2AKDM4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR FFAR1 33/4885FFAR4 44/4885PPARA 397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.