SCHEMBL377642

SCHEMBL377642

O=C1NC(Cc2cnc3cc(OCc4ccccc4)ccc3c2)C(=O)S1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.46
ALOX5 P09917 1/20 0.41
MAOB P27338 10/20 0.41
PTPN1 P18031 2/20 0.40
IP6K1 Q92551 1/20 0.40
MAOA P21397 5/20 0.40
CA12 O43570 2/20 0.40
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA7 P43166 2/20 0.40
CA9 Q16790 2/20 0.40
MEN1 O00255 1/20 0.40
NPC1 O15118 1/20 0.40
CA3 P07451 1/20 0.40
CA4 P22748 1/20 0.40
CA6 P23280 1/20 0.40
MTNR1A P48039 1/20 0.40
KMT2A Q03164 1/20 0.40
CA14 Q9ULX7 1/20 0.40
HPGD P15428 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL377641 0.79 FFAR1 (0.59) CYP3A4
SCHEMBL29602962 0.79 FFAR1 (0.59) CYP3A4
SCHEMBL6965067 0.77 CYP3A4 (0.46) CYP3A4ALOX5MAOBIP6K1MAOA
SCHEMBL6959497 0.76 MAOB (0.55) CYP3A4ALOX5MAOBMAOA
SCHEMBL6956120 0.74 FFAR1 (0.63)
SCHEMBL1746646 0.74 FFAR1 (0.63) PTPN1MEN1KMT2AHPGD
SCHEMBL305465 0.74 PTPN1 (0.53) MAOBPTPN1
SCHEMBL18571362 0.73 CYP3A4 (0.61) CYP3A4ALOX5MAOBNPC1PDGFRB
SCHEMBL1747427 0.73 FFAR1 (0.52) PTPN1MEN1KMT2AHPGD
SCHEMBL4940660 0.72 GAA (0.44) CYP3A4MAOBCA2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6121288-A DECREASING VISCERAL FAT, INHIBITING ACCUMULATION OF VISCERAL FAT AND IMPROVING THE DISTRIBUTION OF VISCERAL FAT BY ADMINISTERING A 5-SUBSTITUTED-2,4-THIAZOLIDINEDIONE DERIVATIVE OF GIVEN FORMULA NIPPON CHEMIPHAR CO., LTD. (JP) 2000-09-19 US claimed
EP-0974348-A1 VISCERAL FAT LOWERING AGENT NIPPON CHEMIPHAR CO., LTD. (JP) 2000-01-26 EP claimed
JP-10182461-A None JP disclosed
US-20230210808-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2023-07-06 US disclosed
US-11007162-B2 Methods of reducing small, dense LDL particles CYMABAY THERAPEUTICS, INC. (US) 2021-05-18 US disclosed
US-20190298672-A1 METHODS OF REDUCING SMALL, DENSE LDL PARTICLES CYMABAY THERAPEUTICS, INC. (US) 2019-10-03 US disclosed
US-20190192475-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2019-06-27 US disclosed
EP-2346498-B1 METHODS OF REDUCING SMALL, DENSE LDL PARTICLES CYMABAY THERAPEUTICS INC (US) 2018-12-26 EP disclosed
US-20170304254-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS JANSSEN PHARMACEUTICA NV (DE) 2017-10-26 US disclosed
US-9724322-B2 4-(phenoxyalkyl)thio)-phenoxyacetic acids and analogs JANSSEN PHARMACEUTICA N.V. (BE) 2017-08-08 US disclosed
US-20160324811-A1 METHODS OF REDUCING SMALL, DENSE LDL PARTICLES CYMABAY THERAPEUTICS, INC. (US) 2016-11-10 US disclosed
WO-2003080070-A2 COMBINATION COMPRISING AN HMG-COA REDUCTASE INHIBITTOR AND AN INSULIN SECRETOR ENHANCER OR AN INSULIN SENSITIZER NOVARTIS AG (CH) 2003-10-02 WO disclosed
US-20030055091-A1 Combination therapy comprising glucose reabsorption inhibitors and retinoid-X receptor modulators ORTHO MCNEIL PHARMACEUTICAL, INC. 2003-03-20 US disclosed
US-20030045553-A1 Combination therapy comprising glucose reabsorption inhibitors and PPAR modulators ORTHO-MCNEIL PHARMACEUITCAL, INC. 2003-03-06 US disclosed
WO-2002080935-A1 COMBINATION THERAPY COMPRISING GLUCOSE REABSORPTION INHIBITORS AND RETINOID-X RECEPTOR MODULATORS ORTHO MCNEIL PHARMACEUTICAL, INC. (US) 2002-10-17 WO disclosed
WO-2002080936-A1 COMBINATION THERAPY COMPRISING GLUCOSE REABSORPTION INHIBITORS AND PPAR MODULATORS ORTHO MCNEIL PHARMACEUTICAL, INC. (US) 2002-10-17 WO disclosed
WO-2000073273-A1 PROCESS FOR THE PREPARATION OF 2-HALO-3-(3-QUINOLYL)PROPIONIC ACID DERIVATIVES NIPPON CHEMIPHAR CO., LTD. (JP) 2000-12-07 WO disclosed
US-6121288-A DECREASING VISCERAL FAT, INHIBITING ACCUMULATION OF VISCERAL FAT AND IMPROVING THE DISTRIBUTION OF VISCERAL FAT BY ADMINISTERING A 5-SUBSTITUTED-2,4-THIAZOLIDINEDIONE DERIVATIVE OF GIVEN FORMULA NIPPON CHEMIPHAR CO., LTD. (JP) 2000-09-19 US disclosed
EP-0974348-A1 VISCERAL FAT LOWERING AGENT NIPPON CHEMIPHAR CO., LTD. (JP) 2000-01-26 EP disclosed
JP-H10182461-A VISCERAL FAT REDUCING AGENT NIPPON CHEMIPHAR CO LTD 1998-07-07 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160324811-A1 METHODS OF REDUCING SMALL, DENSE LDL PARTICLES LDLR, APOB, HDLBP CYP3A4 4563/4885ALOX5 570/4885MAOB 1981/4885
US-20190298672-A1 METHODS OF REDUCING SMALL, DENSE LDL PARTICLES LDLR, APOB, HDLBP CYP3A4 4563/4885ALOX5 570/4885MAOB 1981/4885
US-20190192475-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD CYP3A4 1163/4885ALOX5 672/4885MAOB 4347/4885
US-20230210808-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD CYP3A4 1163/4885ALOX5 672/4885MAOB 4347/4885
US-20030055091-A1 Combination therapy comprising glucose reabsorption inhibitors and retinoid-X receptor modulators GPR119, SLC2A4, SLC2A1 CYP3A4 1782/4885ALOX5 3653/4885MAOB 3968/4885
US-11007162-B2 Methods of reducing small, dense LDL particles LDLR, APOB, HDLBP CYP3A4 4563/4885ALOX5 570/4885MAOB 1981/4885
US-20030045553-A1 Combination therapy comprising glucose reabsorption inhibitors and PPAR modulators GPR119, SLC2A4, PPARG CYP3A4 2012/4885ALOX5 2425/4885MAOB 3427/4885
US-20170304254-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD CYP3A4 1163/4885ALOX5 672/4885MAOB 4347/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.