Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Phenosafranine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.39 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.39 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenosafranine SCHEMBL3139756 | 0.98 | RAB9A (0.69) | RAB9ANPC1L3MBTL1NLRP3MAPT | |
| Phenosafranine SCHEMBL29588207 | 0.98 | RAB9A (0.69) | RAB9ANPC1L3MBTL1NLRP3MAPT | |
| Phenosafranine SCHEMBL41415 | 0.98 | RAB9A (0.69) | RAB9ANPC1L3MBTL1NLRP3MAPT | |
| Phenosafranine SCHEMBL29424348 | 0.98 | RAB9A (0.69) | RAB9ANPC1L3MBTL1NLRP3MAPT | |
| Phenosafranine SCHEMBL466891 | 0.96 | RAB9A (0.68) | RAB9ANPC1L3MBTL1NLRP3MAPT | |
| SCHEMBL19052327 | 0.93 | NPC1 (0.64) | RAB9ANPC1L3MBTL1NLRP3MAPT | |
| Phenosafranine SCHEMBL11597066 | 0.90 | RAB9A (0.61) | RAB9ANPC1L3MBTL1NLRP3MAPT | |
| SCHEMBL10005184 | 0.89 | NPC1 (0.64) | RAB9ANPC1L3MBTL1NLRP3MAPT | |
| SCHEMBL20969285 | 0.85 | NPC1 (0.60) | RAB9ANPC1L3MBTL1NLRP3MAPT | |
| SCHEMBL6158097 | 0.85 | RAB9A (0.56) | RAB9ANPC1L3MBTL1NLRP3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170275410-A1 | POLYMERS, SUBSTRATES, METHODS FOR MAKING SUCH, AND DEVICES COMPRISING THE SAME | Avertica, Inc. | 2017-09-28 | — | — | US | claimed |
| WO-2016019128-A1 | POLYMERS, SUBSTRATES, METHODS FOR MAKING SUCH, AND DEVICES COMPRISING THE SAME | AVERTICA INC. (US) | 2016-02-04 | — | — | WO | claimed |
| US-10570241-B2 | Polymers, substrates, methods for making such, and devices comprising the same | AVERTICA INC. (US) | 2020-02-25 | — | — | US | disclosed |
| US-20170275410-A1 | POLYMERS, SUBSTRATES, METHODS FOR MAKING SUCH, AND DEVICES COMPRISING THE SAME | Avertica, Inc. | 2017-09-28 | — | — | US | disclosed |
| WO-2016019128-A1 | POLYMERS, SUBSTRATES, METHODS FOR MAKING SUCH, AND DEVICES COMPRISING THE SAME | AVERTICA INC. (US) | 2016-02-04 | — | — | WO | disclosed |