Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGALS9 | O00182 | 1/20 | 0.38 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.38 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.38 |
| ▸ | LGALS7; LGALS7B | P47929 | 1/20 | 0.38 |
| ▸ | HK1 | P19367 | 1/20 | 0.37 |
| ▸ | HK2 | P52789 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17465396 | 1.00 | LGALS9 (0.38) | LGALS9LGALS1LGALS3LGALS7; LGALS7BHK1 | |
| SCHEMBL17465435 | 0.92 | BRD4 (0.35) | ADORA1ADORA3ADORA2ABRD4PDPK1 | |
| SCHEMBL17465407 | 0.92 | PDPK1 (0.35) | ADORA1ADORA3ADORA2ABRD4PDPK1 | |
| SCHEMBL17465432 | 0.90 | BRD4 (0.35) | ADORA1ADORA3ADORA2ABRD4PDPK1 | |
| SCHEMBL17465397 | 0.84 | SMN1; SMN2 (0.35) | ADORA1ADORA3ADORA2ABRD4PDPK1 | |
| SCHEMBL21837294 | 0.84 | PRMT6 (0.33) | ADORA1BRD4PDPK1 | |
| SCHEMBL21837296 | 0.82 | TYMP (0.42) | ADORA1ADORA3ADORA2ABRD4 | |
| SCHEMBL19644596 | 0.81 | BRD4 (0.35) | ADORA1ADORA3ADORA2ABRD4PDPK1 | |
| SCHEMBL17465401 | 0.79 | BRD4 (0.35) | ADORA1ADORA3ADORA2ABRD4PDPK1 | |
| SCHEMBL17465394 | 0.79 | PDPK1 (0.39) | ADORA1ADORA3ADORA2ABRD4PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4023650-A1 | 4'-SUBSTITUTED-FURO[3,2-D]PYRIMIDINE AND -PYRROLO[3,2- D]PYRIMIDINE DERIVATIVES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | Gilead Sciences, Inc. (US) | 2022-07-06 | — | — | EP | disclosed |
| EP-3693367-B1 | THIENO [3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES INC (US) | 2022-02-16 | — | — | EP | disclosed |
| EP-3174870-B1 | THIENO [3,2-D]PYRIMIDINES, FURO [3,2,D]PYRIMIDINES AND PYRROLO [3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES INC (US) | 2020-04-15 | — | — | EP | disclosed |
| EP-3174870-A1 | THIENO [3,2-D]PYRIMIDINE, FURO [3,2,D]PYRIMIDINE, AND PYRROLO [3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | Gilead Sciences, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |
| WO-2016018697-A1 | THIENO [3,2-D] PYRIMIDINE, FURO [3,2,D] PYRIMIDINE, AND PYRROLO [3,2-D] PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES, INC. (US) | 2016-02-04 | — | — | WO | disclosed |