Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | FAAH | O00519 | 7/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174817 | 0.84 | NPC1 (0.49) | NPC1RAB9ATAAR1GAAMAPT | |
| SCHEMBL1895641 | 0.82 | TAAR1 (0.58) | NPC1RAB9ATAAR1GAA | |
| SCHEMBL7998297 | 0.79 | RAB9A (0.60) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL153841 | 0.78 | MGLL (0.61) | NPC1RAB9ATAAR1GAASMN1; SMN2 | |
| SCHEMBL3961218 | 0.78 | FFAR1 (0.64) | NPC1RAB9AGAAMAPTKMT2A | |
| SCHEMBL5219284 | 0.77 | FAAH (0.78) | NPC1RAB9AFAAH | |
| SCHEMBL20766426 | 0.77 | FAAH (0.70) | NPC1RAB9AFAAH | |
| SCHEMBL4446760 | 0.76 | MEN1 (0.55) | NPC1RAB9ATAAR1GAAMAPT | |
| SCHEMBL25222344 | 0.76 | RAB9A (0.58) | NPC1RAB9ATAAR1GAASMN1; SMN2 | |
| SCHEMBL27134652 | 0.76 | MGLL (0.58) | GAAFAAHL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424842-A2 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | Aerie Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126626-A2 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | AERIE PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |