Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 13/20 | 0.39 |
| ▸ | CTSK | P43235 | 11/20 | 0.39 |
| ▸ | CTSB | P07858 | 4/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15932451 | 0.79 | CTSS (0.40) | CTSSCTSKCTSBCTSLPTGDR2 | |
| SCHEMBL17474203 | 0.70 | CTSS (0.41) | CTSSCTSKCTSBCTSLMMP13 | |
| SCHEMBL20997615 | 0.70 | CTSS (0.41) | CTSSCTSKCTSBCTSLMMP13 | |
| SCHEMBL30570497 | 0.69 | CTSS (0.42) | CTSSCTSKCTSBCTSLMMP13 | |
| SCHEMBL17474200 | 0.69 | CTSS (0.42) | CTSSCTSKCTSBCTSLMMP13 | |
| SCHEMBL17476298 | 0.68 | KMT2A (0.40) | CTSSCTSKCTSBCTSLMMP13 | |
| SCHEMBL30570520 | 0.68 | TRPV4 (0.40) | CTSSCTSKCTSBCTSL | |
| SCHEMBL17477724 | 0.68 | TRPV4 (0.40) | CTSSCTSKCTSBCTSL | |
| SCHEMBL20997532 | 0.68 | CTSS (0.44) | CTSSCTSKCTSBCTSLMMP13 | |
| SCHEMBL15913295 | 0.68 | TBXA2R (0.41) | PTGDR2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016016365-A1 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-02-04 | — | — | WO | disclosed |
| WO-2016016368-A1 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-02-04 | — | — | WO | disclosed |