Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 17/20 | 0.44 |
| ▸ | CTSK | P43235 | 15/20 | 0.44 |
| ▸ | CTSB | P07858 | 4/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20997615 | 0.90 | CTSS (0.41) | CTSSCTSKCTSBCTSLMMP13 | |
| SCHEMBL21504982 | 0.81 | CTSS (0.46) | CTSSCTSKCTSBCTSLMMP13 | |
| SCHEMBL21665877 | 0.81 | CTSS (0.43) | CTSSCTSKCTSBCTSLMMP13 | |
| SCHEMBL26227418 | 0.80 | CTSS (0.43) | CTSSCTSKCTSBCTSL | |
| SCHEMBL7995586 | 0.69 | CTSK (0.54) | CTSSCTSKCTSBCTSLMMP13 | |
| SCHEMBL17481859 | 0.68 | CTSS (0.39) | CTSSCTSKCTSBCTSLMMP13 | |
| SCHEMBL17474203 | 0.67 | CTSS (0.41) | CTSSCTSKCTSBCTSLMMP13 | |
| SCHEMBL7943806 | 0.65 | CTSS (0.49) | CTSSCTSKCTSBCTSLMMP13 | |
| SCHEMBL17476298 | 0.65 | KMT2A (0.40) | CTSSCTSKCTSBCTSLMMP13 | |
| SCHEMBL17474200 | 0.64 | CTSS (0.42) | CTSSCTSKCTSBCTSLMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539952-B1 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2022-06-22 | — | — | EP | disclosed |
| EP-3174861-B1 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2019-05-15 | — | — | EP | disclosed |