Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17474430 | 0.92 | PLK1 (0.34) | PLK1SIGMAR1 | |
| SCHEMBL17482010 | 0.76 | CHEK1 (0.38) | PLK1 | |
| SCHEMBL17482018 | 0.73 | KCNK2 (0.33) | — | |
| SCHEMBL17482019 | 0.73 | DRD2 (0.39) | — | |
| SCHEMBL17482024 | 0.72 | KCNK2 (0.42) | — | |
| SCHEMBL17704935 | 0.72 | RORA (0.46) | SIGMAR1 | |
| SCHEMBL16169648 | 0.71 | HASPIN (0.41) | SIGMAR1 | |
| SCHEMBL13374193 | 0.69 | ALDH1A1 (0.41) | — | |
| SCHEMBL16156822 | 0.69 | PSEN1 (0.38) | PLK1 | |
| SCHEMBL14689593 | 0.68 | MAPT (0.42) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9862684-B2 | Modulation of K2P channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-01-09 | — | — | US | disclosed |
| US-20160031814-A1 | MODULATION OF K2P CHANNELS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031814-A1 | MODULATION OF K2P CHANNELS | KCNJ2, KCNK2, KCNN3 | PLK1 404/4885SIGMAR1 1278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.