Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GALK1 | P51570 | 8/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2311135 | 0.84 | DGAT1 (0.44) | DGAT1SMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL1748140 | 0.83 | DGAT1 (0.58) | DGAT1SMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL1748237 | 0.80 | DGAT1 (0.49) | DGAT1SMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL12315617 | 0.79 | DGAT1 (0.46) | DGAT1SMN1; SMN2KDM4EALDH1A1MAPT | |
| Bicarbonate SCHEMBL2359226 | 0.77 | DGAT1 (0.42) | DGAT1MAPTNPC1RAB9ADYRK3 | |
| SCHEMBL2308158 | 0.76 | DGAT1 (0.56) | DGAT1MAPTNPC1RAB9ADYRK3 | |
| SCHEMBL1748065 | 0.76 | DGAT1 (0.41) | DGAT1SMN1; SMN2KDM4EMAPTHSD17B10 | |
| SCHEMBL2309580 | 0.76 | DGAT1 (0.41) | DGAT1KDM4EHSD17B10 | |
| Bicarbonate SCHEMBL2314871 | 0.75 | DGAT1 (0.51) | DGAT1SMN1; SMN2GALK1CSF1RHDAC6 | |
| SCHEMBL2309693 | 0.74 | DGAT1 (0.67) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013166-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER HEALTHCARE LLC (US) | 2011-09-06 | — | — | US | disclosed |
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | disclosed |