Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 8/20 | 0.39 |
| ▸ | RAB9A | P51151 | 8/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2310230 | 0.83 | NPC1 (0.52) | DGAT1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL1748153 | 0.81 | DGAT1 (0.59) | DGAT1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL5984327 | 0.81 | DGAT1 (0.59) | DGAT1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL1748064 | 0.79 | DGAT1 (0.48) | DGAT1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL2309580 | 0.77 | DGAT1 (0.41) | DGAT1KDM4EHSD17B10 | |
| SCHEMBL1748238 | 0.76 | DGAT1 (0.42) | DGAT1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1748122 | 0.75 | DGAT1 (0.50) | DGAT1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1748172 | 0.74 | DGAT1 (0.36) | DGAT1KDM4EHSD17B10HDAC6 | |
| SCHEMBL1747988 | 0.73 | DGAT1 (0.72) | DGAT1SMN1; SMN2KDM4EMEN1KMT2A | |
| Bicarbonate SCHEMBL2307118 | 0.72 | DGAT1 (0.46) | DGAT1NPC1RAB9ASMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013166-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER HEALTHCARE LLC (US) | 2011-09-06 | — | — | US | disclosed |
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | disclosed |