Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16582826 | 0.84 | ACHE (0.38) | KMT2AMEN1NPC1RAB9AHPRT1 | |
| SCHEMBL16582710 | 0.82 | CYP1B1 (0.34) | KMT2AMEN1NPC1RAB9AHPRT1 | |
| SCHEMBL17971402 | 0.78 | SMN1; SMN2 (0.37) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL16905566 | 0.76 | KMT2A (0.36) | KMT2AMEN1NPC1RAB9AHPRT1 | |
| SCHEMBL17971395 | 0.75 | CCR1 (0.35) | KMT2AMEN1NPC1MAPTL3MBTL1 | |
| SCHEMBL17971401 | 0.75 | ALDH1A1 (0.35) | L3MBTL1ALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL16582573 | 0.75 | KDM4E (0.33) | KMT2AMEN1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL19859937 | 0.74 | — | — | |
| SCHEMBL18309494 | 0.73 | KMT2A (0.33) | KMT2AMEN1NPC1RAB9AHPRT1 | |
| SCHEMBL19561599 | 0.73 | KMT2A (0.33) | KMT2AMEN1NPC1RAB9AHPRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11005050-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2021-05-11 | — | — | US | disclosed |
| EP-3174890-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2019-03-13 | — | — | EP | disclosed |
| US-9893299-B2 | Heterocyclic compounds | MERCK PATENT GMBH (DE) | 2018-02-13 | — | — | US | disclosed |
| US-9893299-B2 | Heterocyclic compounds | MERCK PATENT GMBH (DE) | 2018-02-13 | — | — | US | disclosed |
| US-9853228-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2017-12-26 | — | — | US | disclosed |
| US-9853228-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2017-12-26 | — | — | US | disclosed |
| EP-3094638-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2017-11-08 | — | — | EP | disclosed |
| US-20170250353-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2017-08-31 | — | — | US | disclosed |
| US-20170250353-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2017-08-31 | — | — | US | disclosed |
| US-20160365520-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2016-12-15 | — | — | US | disclosed |
| US-20160365520-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2016-12-15 | — | — | US | disclosed |
| US-20160226003-A1 | HETEROCYCLIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-08-04 | — | — | US | disclosed |
| US-20160226003-A1 | HETEROCYCLIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-08-04 | — | — | US | disclosed |
| WO-2016015815-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2016-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160226003-A1 | HETEROCYCLIC COMPOUNDS | ERCC1, VDAC2, NES | KMT2A 1631/4885MEN1 733/4885NPC1 2793/4885 |
| US-11005050-B2 | Metal complexes | SOD1, AP1M1, AP3M1 | KMT2A 2922/4885MEN1 989/4885NPC1 3516/4885 |
| US-20160365520-A1 | METAL COMPLEXES | SOD1, AP1M1, AP3M1 | KMT2A 2922/4885MEN1 989/4885NPC1 3516/4885 |
| US-20170250353-A1 | METAL COMPLEXES | SOD1, AP1M1, AP3M1 | KMT2A 2922/4885MEN1 989/4885NPC1 3516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.