Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 9/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL968115 | 0.82 | HTR2A (0.47) | HTR2AHTR2CHTR6KDM4EALOX15 | |
| SCHEMBL19271273 | 0.80 | DDB1 (0.46) | HTR2AHTR2CHTR6KDM4EMAPK1 | |
| SCHEMBL17489603 | 0.79 | HTR6 (0.39) | HDAC1HDAC6HTR2AHTR2CHTR6 | |
| SCHEMBL14891192 | 0.78 | ENPP2 (0.57) | HTR2AHTR6KDM4EENPP2 | |
| Hydrochloric Acid SCHEMBL14891041 | 0.78 | ENPP2 (0.56) | HTR2AHTR6KDM4EENPP2 | |
| SCHEMBL9615137 | 0.77 | HTR2A (0.55) | HDAC1HDAC6HTR2AHTR2CHTR6 | |
| SCHEMBL26017343 | 0.77 | HRH1 (0.45) | HTR6KDM4EENPP2HTR5A | |
| Hydrochloric Acid SCHEMBL9696491 | 0.76 | KDM4E (0.56) | HDAC1HDAC6HTR2AHTR2CHTR6 | |
| SCHEMBL17486945 | 0.76 | ENPP2 (0.46) | HDAC1HDAC6HTR6KDM4EENPP2 | |
| SCHEMBL26347704 | 0.75 | HDAC1 (0.39) | HDAC1HDAC6KDM4EHSD17B10HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9862721-B2 | Tetrahydrocarboline derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2018-01-09 | — | — | US | disclosed |
| US-9353113-B2 | Tetrahydrocarboline derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2016-05-31 | — | — | US | disclosed |
| US-20160031884-A1 | TETRAHYDROCARBOLINE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031884-A1 | TETRAHYDROCARBOLINE DERIVATIVE | ENPP2, ENPP1, ACER2 | HDAC1 1652/4885HDAC6 1626/4885HTR2A 1208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.