Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16132336 | 0.77 | BRD4 (0.39) | TSHRBRD4TP53HPGD | |
| SCHEMBL16132467 | 0.76 | BRD4 (0.37) | TSHRBRD4TP53HPGDATAD2 | |
| SCHEMBL16132402 | 0.76 | — | — | |
| SCHEMBL16132333 | 0.70 | CYP11B2 (0.37) | BRD4TP53HPGD | |
| SCHEMBL31528092 | 0.64 | NR1I2 (0.34) | — | |
| SCHEMBL25085404 | 0.62 | TSHR (0.31) | TSHR | |
| SCHEMBL31419462 | 0.61 | ATAD2 (0.50) | BRD4ATAD2 | |
| SCHEMBL17487243 | 0.61 | — | — | |
| SCHEMBL16132326 | 0.59 | KIF11 (0.41) | TSHRBRD4 | |
| SCHEMBL14314162 | 0.57 | GABRA1 (0.35) | TSHRATAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160031868-A1 | BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031868-A1 | BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD1 | TSHR 2414/4885BRD4 1/4885TP53 1216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.