Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1198090 | 0.83 | GSK3B (0.58) | NPC1RAB9AHPGDSMN1; SMN2GSK3B | |
| SCHEMBL15143918 | 0.83 | SMN1; SMN2 (0.79) | NPC1RAB9AHPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL9674322 | 0.81 | SMN1; SMN2 (0.61) | NPC1RAB9AHPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL18152990 | 0.80 | GSK3B (0.50) | RAB9ASMN1; SMN2GSK3BALDH1A1LMNA | |
| SCHEMBL11953212 | 0.80 | NPC1 (0.65) | NPC1RAB9AHPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL19138068 | 0.79 | GSK3B (0.49) | RAB9ASMN1; SMN2GSK3BALDH1A1LMNA | |
| SCHEMBL17382567 | 0.79 | ALDH1A1 (0.58) | RAB9AHPGDSMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL17382560 | 0.78 | CYP17A1 (0.51) | GSK3BPTPN1 | |
| SCHEMBL9435974 | 0.77 | RAB9A (0.62) | NPC1RAB9AHPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL5023024 | 0.77 | HPGD (0.65) | NPC1RAB9AHPGDSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180317-B1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME (US) | 2021-04-14 | — | — | EP | disclosed |
| US-9868727-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-01-16 | — | — | US | disclosed |
| US-20170210732-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-07-27 | — | — | US | disclosed |
| WO-2016015593-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210732-A1 | Factor XIa Inhibitors | F11, SERPINC1, TFPI | NPC1 1211/4885RAB9A 1961/4885HPGD 1374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.