Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | RAPGEF4 | Q8WZA2 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3500880 | 0.87 | L3MBTL1 (0.66) | L3MBTL1RAPGEF4PKMCYP2C19BRD4 | |
| SCHEMBL1960656 | 0.86 | CYP2C19 (0.61) | L3MBTL1RAPGEF4PKMCYP2C19POLB | |
| SCHEMBL28383297 | 0.84 | L3MBTL1 (0.61) | L3MBTL1RAPGEF4PKMCYP2C19BRD4 | |
| SCHEMBL12696586 | 0.84 | L3MBTL1 (0.61) | L3MBTL1RAPGEF4PKMCYP2C19BRD4 | |
| SCHEMBL1713486 | 0.84 | L3MBTL1 (0.61) | L3MBTL1RAPGEF4PKMCYP2C19BRD4 | |
| SCHEMBL29605995 | 0.84 | L3MBTL1 (0.61) | L3MBTL1RAPGEF4PKMCYP2C19BRD4 | |
| SCHEMBL14487894 | 0.84 | L3MBTL1 (0.61) | L3MBTL1RAPGEF4PKMCYP2C19BRD4 | |
| SCHEMBL28325512 | 0.84 | L3MBTL1 (0.61) | L3MBTL1RAPGEF4PKMCYP2C19BRD4 | |
| SCHEMBL3500069 | 0.83 | L3MBTL1 (0.57) | L3MBTL1RAPGEF4PKMCYP2C19BRD4 | |
| SCHEMBL28555533 | 0.82 | L3MBTL1 (0.56) | L3MBTL1RAPGEF4PKMCYP2C19BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134730-A1 | IMPROVED PROCESS FOR PREPARING BORYL 7-AZAINDOLE COMPOUNDS | BOROPHARM INC (US) | 2018-05-17 | — | — | US | claimed |
| WO-2025096463-A1 | PLK4 MODULATORS | VIBLIOME THERAPEUTICS, LLC (US) | 2025-05-08 | — | — | WO | disclosed |
| CN-117362318-A | PB2 inhibitor and preparation method and application thereof | 西藏海思科制药有限公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-115698011-B | PB2 inhibitor and preparation method and application thereof | 四川海思科制药有限公司 | 2023-10-20 | — | — | CN | disclosed |
| US-20230265107-A1 | PB2 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2023-08-24 | — | — | US | disclosed |
| US-20230265107-A1 | PB2 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2023-08-24 | — | — | US | disclosed |
| EP-4180434-A1 | PB2 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Sichuan Haisco Pharmaceutical Co., Ltd. (CN) | 2023-05-17 | — | — | EP | disclosed |
| CN-115698011-A | PB2 inhibitor and preparation method and application thereof | 四川海思科制药有限公司 | 2023-02-03 | — | — | CN | disclosed |
| US-11345700-B2 | Methods of preparing inhibitors of influenza viruses replication | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-05-31 | — | — | US | disclosed |
| EP-3851437-A2 | METHODS OF PREPARING 1H-PYRROLO[2,3-B]PYRIDINE DERIVATES | Vertex Pharmaceuticals Incorporated (US) | 2021-07-21 | — | — | EP | disclosed |
| US-7968566-B2 | Pyrrolo(2,3-b) pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors | AVENTIS PHARMA S.A. (FR) | 2011-06-28 | — | — | US | disclosed |
| US-20100256141-A1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2010-10-07 | — | — | US | disclosed |
| US-7786114-B2 | Bis-azaindole derivatives, preparation and pharmaceutical use thereof as kinase inhibitors | AVENTIS PHARMA S.A. (FR) | 2010-08-31 | — | — | US | disclosed |
| US-20090233956-A1 | NOVEL PYRROLO(2,3-b) PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2009-09-17 | — | — | US | disclosed |
| US-7528147-B2 | Pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors | AVENTIS PHARMA S.A. (FR) | 2009-05-05 | — | — | US | disclosed |
| US-20080045561-A1 | Novel Bis-Azaindole Derivatives, Preparation And Pharmaceutical Use Thereof As Kinase Inhibitors | AVENTIS PHARMA S.A. (FR) | 2008-02-21 | — | — | US | disclosed |
| EP-1799691-A1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2007-06-27 | — | — | EP | disclosed |
| US-20070093480-A1 | Novel pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors | AVENTIS PHARMA S.A. (FR) | 2007-04-26 | — | — | US | disclosed |
| CN-1950083-A | Novel pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors | AVENTIS PHARMA SA (FR) | 2007-04-18 | — | — | CN | disclosed |
| WO-2006037875-A1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2006-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045561-A1 | Novel Bis-Azaindole Derivatives, Preparation And Pharmaceutical Use Thereof As Kinase Inhibitors | BRSK2, KSR2, CDK2 | L3MBTL1 4205/4885RAPGEF4 554/4885PKM 618/4885 |
| US-20090233956-A1 | NOVEL PYRROLO(2,3-b) PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | MAP3K19, MAP4K2, MAP3K1 | L3MBTL1 4601/4885RAPGEF4 690/4885PKM 282/4885 |
| US-20100256141-A1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | BRSK2, KSR2, CDK2 | L3MBTL1 4205/4885RAPGEF4 554/4885PKM 618/4885 |
| US-20230265107-A1 | PB2 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | CYP11B2, WEE2, CYP11B1 | L3MBTL1 1316/4885RAPGEF4 3693/4885PKM 1539/4885 |
| US-20180134730-A1 | IMPROVED PROCESS FOR PREPARING BORYL 7-AZAINDOLE COMPOUNDS | AZI2, BCCIP, ADAR | L3MBTL1 1781/4885RAPGEF4 315/4885PKM 3112/4885 |
| US-11345700-B2 | Methods of preparing inhibitors of influenza viruses replication | ZC3HAV1, ZC3HAV1L, POLR2H | L3MBTL1 3307/4885RAPGEF4 961/4885PKM 801/4885 |
| US-20070093480-A1 | Novel pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors | MAP3K19, MAP4K2, MAP3K1 | L3MBTL1 4601/4885RAPGEF4 690/4885PKM 282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.