Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 13/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30138150 | 1.00 | RAB9A (0.44) | RAB9AKDM4ENPC1MAPTCASP6 | |
| SCHEMBL17492326 | 0.86 | RAB9A (0.60) | RAB9AKDM4ENPC1MAPTSUV39H2 | |
| SCHEMBL17492282 | 0.83 | KDM4E (0.51) | RAB9AKDM4ENPC1MAPTSUV39H2 | |
| SCHEMBL17492312 | 0.82 | RAB9A (0.56) | RAB9AKDM4ENPC1MAPTCASP6 | |
| SCHEMBL28401383 | 0.78 | RAB9A (0.45) | RAB9AKDM4ENPC1MAPTSUV39H2 | |
| SCHEMBL28889673 | 0.78 | RAB9A (0.45) | RAB9AKDM4ENPC1MAPTSUV39H2 | |
| SCHEMBL28889668 | 0.77 | RAB9A (0.44) | RAB9AKDM4ENPC1MAPTSUV39H2 | |
| SCHEMBL1691818 | 0.76 | LMNA (0.53) | RAB9AKDM4ENPC1MAPTSUV39H2 | |
| SCHEMBL22490654 | 0.75 | SUV39H2 (0.38) | RAB9AKDM4ENPC1MAPTSUV39H2 | |
| SCHEMBL28396792 | 0.74 | TLR9 (0.61) | RAB9AKDM4ENPC1PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10413536-B2 | 6-alkyny-pyridine derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-09-17 | — | — | US | disclosed |
| US-10413536-B2 | 6-alkyny-pyridine derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-09-17 | — | — | US | disclosed |
| EP-3180339-B1 | 6-ALKYNYL-PYRIDINE DERIVATIVES AS SMAC MIMETICS | BOEHRINGER INGELHEIM INT (DE) | 2018-12-05 | — | — | EP | disclosed |
| US-20180015082-A1 | 6-Alkynyl-pyridine Derivatives | BOEHRINGER INGELHEIM INT (DE) | 2018-01-18 | — | — | US | disclosed |
| US-20180015082-A1 | 6-Alkynyl-pyridine Derivatives | BOEHRINGER INGELHEIM INT (DE) | 2018-01-18 | — | — | US | disclosed |
| US-20180015082-A1 | 6-Alkynyl-pyridine Derivatives | BOEHRINGER INGELHEIM INT (DE) | 2018-01-18 | — | — | US | disclosed |
| US-9801871-B2 | 6-alkynyl-pyridine derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-10-31 | — | — | US | disclosed |
| US-9801871-B2 | 6-alkynyl-pyridine derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-10-31 | — | — | US | disclosed |
| US-9801871-B2 | 6-alkynyl-pyridine derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-10-31 | — | — | US | disclosed |
| US-20170020859-A1 | 6-ALKYNYL-PYRIDINE DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2017-01-26 | — | — | US | disclosed |
| US-20170020859-A1 | 6-ALKYNYL-PYRIDINE DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2017-01-26 | — | — | US | disclosed |
| US-20170020859-A1 | 6-ALKYNYL-PYRIDINE DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2017-01-26 | — | — | US | disclosed |
| US-9481673-B2 | 6-alkynyl-pyridine derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-11-01 | — | — | US | disclosed |
| US-9481673-B2 | 6-alkynyl-pyridine derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-11-01 | — | — | US | disclosed |
| US-9481673-B2 | 6-alkynyl-pyridine derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-11-01 | — | — | US | disclosed |
| WO-2016023858-A1 | 6-ALKYNYL-PYRIDINE DERIVATIVES AS SMAC MIMETICS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-02-18 | — | — | WO | disclosed |
| US-20160039814-A1 | 6-ALKYNYL-PYRIDINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170020859-A1 | 6-ALKYNYL-PYRIDINE DERIVATIVES | MKI67, TFAM, MCL1 | RAB9A 3193/4885KDM4E 1277/4885NPC1 1668/4885 |
| US-20180015082-A1 | 6-Alkynyl-pyridine Derivatives | MKI67, TFAM, MCL1 | RAB9A 3193/4885KDM4E 1277/4885NPC1 1668/4885 |
| US-20160039814-A1 | 6-ALKYNYL-PYRIDINE DERIVATIVES | MKI67, TFAM, MCL1 | RAB9A 3193/4885KDM4E 1277/4885NPC1 1668/4885 |
| US-10413536-B2 | 6-alkyny-pyridine derivatives | MKI67, TFAM, MCL1 | RAB9A 2835/4885KDM4E 925/4885NPC1 1772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.