Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17494760 | 1.00 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ACYP2C9ENPP3 | |
| SCHEMBL17504885 | 0.94 | TSHR (0.46) | ALDH1A1MEN1KMT2ACYP2C9ENPP3 | |
| SCHEMBL15972573 | 0.86 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2ACYP2C9ENPP3 | |
| SCHEMBL19411360 | 0.86 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2ACYP2C9ENPP3 | |
| SCHEMBL15972575 | 0.86 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2ACYP2C9ENPP3 | |
| SCHEMBL19179863 | 0.81 | ENPP3 (0.46) | ALDH1A1CYP2C9ENPP3ENPP1ENPP2 | |
| SCHEMBL11248469 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2ACYP2C9ENPP3 | |
| SCHEMBL7319789 | 0.73 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2AENPP3ENPP1 | |
| Acetic Acid SCHEMBL10733614 | 0.73 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2ASTAT3POLB | |
| SCHEMBL5510733 | 0.73 | ENPP3 (0.51) | ALDH1A1MEN1KMT2AENPP3ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177287-B1 | ANTIDIABETIC BICYCLIC COMPOUNDS | MERCK SHARP & DOHME (US) | 2022-02-23 | — | — | EP | disclosed |
| US-10968193-B2 | Antidiabetic bicyclic compounds | MERCK SHARP & DOHME CORP. (US) | 2021-04-06 | — | — | US | disclosed |
| US-20170217918-A1 | ANTIDIABETIC BICYCLIC COMPOUNDS | MERCK SHARP & DOHME LLC | 2017-08-03 | — | — | US | disclosed |
| EP-3177287-A1 | ANTIDIABETIC BICYCLIC COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2017-06-14 | — | — | EP | disclosed |
| WO-2016022742-A1 | ANTIDIABETIC BICYCLIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10968193-B2 | Antidiabetic bicyclic compounds | GPR119, GPR65, GLP1R | ALDH1A1 2872/4885MEN1 4443/4885KMT2A 3653/4885 |
| US-20170217918-A1 | ANTIDIABETIC BICYCLIC COMPOUNDS | GPR119, GLP1R, GPR65 | ALDH1A1 2819/4885MEN1 4523/4885KMT2A 3585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.