Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 1/20 | 0.52 |
| ▸ | RHEB | Q15382 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | ATP4A | P20648 | 1/20 | 0.43 |
| ▸ | ATP4B | P51164 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566032 | 0.88 | CYP4F2 (0.45) | S1PR4RHEBPTGER1NPC1NFKB1 | |
| SCHEMBL6883736 | 0.85 | MAPK14 (0.43) | S1PR4PTGER1NPC1NFKB1RAB9A | |
| SCHEMBL2904391 | 0.84 | ATP4A (0.43) | RHEBPTGER1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8694664 | 0.83 | S1PR4 (0.51) | S1PR4RHEBPTGER1NPC1RAB9A | |
| SCHEMBL2026551 | 0.83 | SMN1; SMN2 (0.54) | RHEBSMN1; SMN2ATP4AATP4BLIPE | |
| SCHEMBL8695151 | 0.83 | USP28 (0.43) | RHEBPTGER1RAB9ASMN1; SMN2ATP4A | |
| SCHEMBL28848218 | 0.81 | MAPT (0.46) | PTGER1NPC1NFKB1RAB9ANFKB2 | |
| SCHEMBL30522860 | 0.81 | MAPT (0.46) | PTGER1NPC1NFKB1RAB9ANFKB2 | |
| Hydrochloric Acid SCHEMBL11833848 | 0.81 | SMN1; SMN2 (0.52) | RHEBSMN1; SMN2ATP4AATP4BLIPE | |
| SCHEMBL6639600 | 0.80 | MAPT (0.44) | PTGER1NPC1NFKB1RAB9ANFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240199576-A1 | NOVEL CYCLOPENTA[C]PYRROL NEGATIVE ALLOSTERIC MODULATORS OF NR2B | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2024-06-20 | — | — | US | disclosed |
| EP-4313042-A1 | NOVEL CYCLOPENTA[C]PYRROL NEGATIVE ALLOSTERIC MODULATORS OF NR2B | Novartis AG (CH) | 2024-02-07 | — | — | EP | disclosed |
| CN-117120053-A | Novel cyclopenta [ c ] pyrrole NR2B negative allosteric modulators | 诺华股份有限公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022204337-A1 | NOVEL CYCLOPENTA[C]PYRROL NEGATIVE ALLOSTERIC MODULATORS OF NR2B | NOVARTIS AG (CH) | 2022-09-29 | — | — | WO | disclosed |
| EP-2970331-B1 | SPIRO AZETIDINE ISOXAZOLE DERIVATIVES AND THEIR USE AS SSTR5 ANTAGONISTS | TAKEDA PHARMACEUTICALS CO (JP) | 2017-05-17 | — | — | EP | disclosed |
| US-9605000-B2 | Spiro azetidine isoxazole derivatives and their use as SSTR antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-03-28 | — | — | US | disclosed |
| US-20160060273-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060273-A1 | HETEROCYCLIC COMPOUND | SSTR5, SSTR1, SSTR2 | S1PR4 781/4885RHEB 2830/4885PTGER1 910/4885 |
| US-20240199576-A1 | NOVEL CYCLOPENTA[C]PYRROL NEGATIVE ALLOSTERIC MODULATORS OF NR2B | GRIN2C, GRIN2B, GRIN2A | S1PR4 1746/4885RHEB 699/4885PTGER1 649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.