Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | PTPRB | P23467 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1749708 | 1.00 | HDAC1 (0.52) | HDAC1HDAC6ESR1ESR2TDP1 | |
| SCHEMBL3910015 | 0.84 | ESR1 (0.65) | ESR1ESR2KMT2ANPC1RAB9A | |
| SCHEMBL15689792 | 0.84 | ESR1 (0.65) | ESR1ESR2KMT2ANPC1RAB9A | |
| SCHEMBL6946548 | 0.84 | PTPRB (0.58) | HDAC1HDAC6ESR1ESR2TDP1 | |
| SCHEMBL14540668 | 0.84 | ESR1 (0.65) | ESR1ESR2KMT2ANPC1RAB9A | |
| SCHEMBL4773227 | 0.82 | KMT2A (0.53) | HDAC1HDAC6ESR1ESR2TDP1 | |
| SCHEMBL180106 | 0.82 | NOS2 (0.52) | ESR1ESR2TDP1KMT2AMEN1 | |
| SCHEMBL20502249 | 0.82 | NOS2 (0.47) | ESR1ESR2ACACBL3MBTL1POLB | |
| SCHEMBL180105 | 0.82 | NOS2 (0.52) | ESR1ESR2TDP1KMT2AMEN1 | |
| SCHEMBL2165509 | 0.82 | HDAC1 (0.40) | HDAC1HDAC6ESR1ESR2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9259000-B2 | Auxin biosynthesis inhibitor | RIKEN (JP) | 2016-02-16 | — | — | US | disclosed |
| US-9259000-B2 | Auxin biosynthesis inhibitor | RIKEN (JP) | 2016-02-16 | — | — | US | disclosed |
| US-9259000-B2 | Auxin biosynthesis inhibitor | RIKEN (JP) | 2016-02-16 | — | — | US | disclosed |
| CN-103502204-B | Growth hormone biosynthesis inhibitor | RIKEN (JP) | 2016-01-20 | — | — | CN | disclosed |
| US-20140031230-A1 | AUXIN BIOSYNTHESIS INHIBITOR | Riken Public University Corporation Yokohama City University | 2014-01-30 | — | — | US | disclosed |
| US-20140031230-A1 | AUXIN BIOSYNTHESIS INHIBITOR | Riken Public University Corporation Yokohama City University | 2014-01-30 | — | — | US | disclosed |
| US-20140031230-A1 | AUXIN BIOSYNTHESIS INHIBITOR | Riken Public University Corporation Yokohama City University | 2014-01-30 | — | — | US | disclosed |
| EP-2682383-A1 | AUXIN BIOSYNTHESIS INHIBITOR | Riken (JP) | 2014-01-08 | — | — | EP | disclosed |
| EP-2682383-A1 | AUXIN BIOSYNTHESIS INHIBITOR | Riken (JP) | 2014-01-08 | — | — | EP | disclosed |
| CN-103502204-A | Auxin biosynthesis inhibitor | RIKEN | 2014-01-08 | — | — | CN | disclosed |
| EP-1638964-B1 | NOVEL COMPOUNDS THAT MODULATE PPAR-GAMMA TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | GALDERMA RES & DEV (FR) | 2011-07-27 | — | — | EP | disclosed |
| US-7973063-B2 | Methods for activating PPAR gamma-type receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-07-05 | — | — | US | disclosed |
| US-7968560-B2 | Compounds that modulate PPARγ-type receptors and cosmetic/pharmaceutical compositions comprising said compounds | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-06-28 | — | — | US | disclosed |
| US-20100247468-A1 | Compounds that modulate PPAR gamma-type receptors and cosmetic/pharmaceutical compositions comprising said compounds | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-09-30 | — | — | US | disclosed |
| US-20100099689-A1 | METHODS OF MODULATING PPAR GAMMA-TYPE RECEPTORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-04-22 | — | — | US | disclosed |
| US-20100035988-A1 | Methods for activating PPAR gamma-type receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-02-11 | — | — | US | disclosed |
| US-7626054-B2 | Biaromatic compounds which activate PPARγ-type receptors and cosmetic/pharmaceutical compositions comprised thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-12-01 | — | — | US | disclosed |
| US-7625914-B2 | Compounds that modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-12-01 | — | — | US | disclosed |
| US-20070112070-A1 | Novel biaromatic compounds which activate PPARy-type receptors and cosmetic/pharmaceutical compositions comprised thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2007-05-17 | — | — | US | disclosed |
| US-20060148862-A1 | Novel compounds that modulate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2006-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112070-A1 | Novel biaromatic compounds which activate PPARy-type receptors and cosmetic/pharmaceutical compositions comprised thereof | PPARG, PPARD, PPARA | HDAC1 523/4885HDAC6 1059/4885ESR1 370/4885 |
| US-20140031230-A1 | AUXIN BIOSYNTHESIS INHIBITOR | AGXT, AOX1, FDPS | HDAC1 3802/4885HDAC6 3932/4885ESR1 1679/4885 |
| US-20100099689-A1 | METHODS OF MODULATING PPAR GAMMA-TYPE RECEPTORS | PPARG, PPARA, PPARD | HDAC1 443/4885HDAC6 858/4885ESR1 815/4885 |
| US-20100035988-A1 | Methods for activating PPAR gamma-type receptors | PPARG, PPARA, PPARD | HDAC1 520/4885HDAC6 977/4885ESR1 612/4885 |
| US-20060148862-A1 | Novel compounds that modulate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof | PPARG, PPARD, PPARA | HDAC1 755/4885HDAC6 1213/4885ESR1 788/4885 |
| US-20100247468-A1 | Compounds that modulate PPAR gamma-type receptors and cosmetic/pharmaceutical compositions comprising said compounds | PPARG, PPARD, PPARA | HDAC1 477/4885HDAC6 1035/4885ESR1 672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.