Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 6/20 | 0.52 |
| ▸ | NOS3 | P29474 | 3/20 | 0.52 |
| ▸ | NOS1 | P29475 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA7 | P43166 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180105 | 1.00 | NOS2 (0.52) | NOS2NOS3NOS1TSHRCA12 | |
| SCHEMBL3910015 | 0.84 | ESR1 (0.65) | TSHRKMT2AESR1ESR2 | |
| SCHEMBL14540668 | 0.84 | ESR1 (0.65) | TSHRKMT2AESR1ESR2 | |
| SCHEMBL15689792 | 0.84 | ESR1 (0.65) | TSHRKMT2AESR1ESR2 | |
| SCHEMBL5888360 | 0.84 | PTPRB (0.58) | NOS2NOS3NOS1TSHRCA12 | |
| SCHEMBL1434710 | 0.83 | TSHR (0.49) | NOS2NOS3NOS1TSHRCA12 | |
| SCHEMBL1749708 | 0.82 | HDAC1 (0.52) | MEN1KMT2AESR1ESR2PPARG | |
| SCHEMBL1678477 | 0.82 | TSHR (0.55) | NOS2NOS3NOS1TSHRCA12 | |
| SCHEMBL20502249 | 0.82 | NOS2 (0.47) | NOS2MEN1KMT2AESR1ESR2 | |
| SCHEMBL8591433 | 0.82 | LDHA (0.61) | PPARGHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023562-A1 | NOVEL PIPERIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2013-01-24 | — | — | US | disclosed |
| US-8314127-B2 | Piperidine derivatives | ASTRAZENECA AB (SE) | 2012-11-20 | — | — | US | disclosed |
| EP-1912941-B1 | PIPERIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2012-11-14 | — | — | EP | disclosed |
| EP-2402316-A1 | Piperidine derivatives | AstraZeneca AB (Publ) (SE) | 2012-01-04 | — | — | EP | disclosed |
| CN-101268049-A | Novel piperidine derivatives | ASTRAZENECA AB (SE) | 2008-09-17 | — | — | CN | disclosed |
| US-20080207688-A1 | Novel Piperidine Derivatives | ASTRAZENECA AB (SE) | 2008-08-28 | — | — | US | disclosed |
| EP-1912941-A1 | NOVEL PIPERIDINE DERIVATIVES | AstraZeneca AB (SE) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007011293-A1 | NOVEL PIPERIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-01-25 | — | — | WO | disclosed |
| US-20060247470-A1 | Process for producing optically active carboxylic acid substituted in 2-position | KANEKA CORPORATION | 2006-11-02 | — | — | US | disclosed |
| US-7094926-B2 | Process for producing optically active carboxylic acid substituted in 2-position | KANEKA CORPORATION (JP) | 2006-08-22 | — | — | US | disclosed |
| US-20030144546-A1 | Process for producing optically active carboxylic acid subtituted in 2-position | KANEKA CORPORATION (JP) | 2003-07-31 | — | — | US | disclosed |
| EP-1251115-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE CARBOXYLIC ACID SUBSTITUTED IN 2-POSITION | KANEKA CORPORATION (JP) | 2002-10-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207688-A1 | Novel Piperidine Derivatives | CCR3, CCR1, CCR4 | NOS2 1386/4885NOS3 536/4885NOS1 1476/4885 |
| US-20030144546-A1 | Process for producing optically active carboxylic acid subtituted in 2-position | HAO2, CA2, HACL2 | NOS2 258/4885NOS3 412/4885NOS1 300/4885 |
| US-20130023562-A1 | NOVEL PIPERIDINE DERIVATIVES | CCR3, CCR1, CCR4 | NOS2 1386/4885NOS3 536/4885NOS1 1476/4885 |
| US-20060247470-A1 | Process for producing optically active carboxylic acid substituted in 2-position | HAO2, CA2, HACL2 | NOS2 195/4885NOS3 482/4885NOS1 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.