Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 10/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17498051 | 0.82 | MAPT (0.39) | MAPTPTGS1PTGS2HTR6PTGDR2 | |
| SCHEMBL30825266 | 0.75 | HTR6 (0.44) | MAPTHTR6KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL17498192 | 0.75 | HTR6 (0.44) | MAPTHTR6KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4561334 | 0.71 | AGTR1 (0.51) | HTR6AGTR1PTGDR2PPARGPPARD | |
| SCHEMBL2358234 | 0.68 | KDM4E (0.48) | MAPTPTGS1PTGS2HTR6AGTR1 | |
| SCHEMBL6894989 | 0.68 | NOD1 (0.60) | AGTR1PPARGPPARDALDH1A1GAA | |
| SCHEMBL28971522 | 0.68 | PTGDR2 (0.52) | HTR6AGTR1PTGDR2PPARGPPARD | |
| SCHEMBL13013982 | 0.67 | PTGDR2 (0.48) | AGTR1PTGDR2KDM4E | |
| SCHEMBL2319772 | 0.67 | KDM4E (0.49) | MAPTPTGS1PTGS2HTR6KDM4E | |
| SCHEMBL6755012 | 0.67 | ALDH1A1 (0.59) | MAPTPTGS1PTGS2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016025933-A2 | SUBSTITUTED POLYCYCLIC ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |