Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22917154 | 0.93 | ACP3 (0.47) | BRD4MEN1KMT2AACP3ADRA1D | |
| SCHEMBL22917201 | 0.91 | MEN1 (0.53) | MEN1KMT2AACP3ALDH1A1HPGD | |
| SCHEMBL28419252 | 0.85 | BRD4 (0.55) | BRD4HDAC4HDAC7HDAC5MEN1 | |
| SCHEMBL2302648 | 0.85 | HDAC4 (0.51) | BRD4HDAC4HDAC7HDAC5MEN1 | |
| SCHEMBL10882007 | 0.85 | BRD4 (0.63) | BRD4HDAC4HDAC7HDAC5MEN1 | |
| SCHEMBL22917146 | 0.85 | TRPM8 (0.44) | MEN1KMT2AACP3S1PR3TRPM8 | |
| SCHEMBL22917155 | 0.83 | HDAC4 (0.53) | HDAC4HDAC7HDAC5MEN1KMT2A | |
| SCHEMBL2303105 | 0.80 | UGT2B7 (0.47) | BRD4HDAC4HDAC7HDAC5MEN1 | |
| SCHEMBL12495860 | 0.79 | ALDH1A1 (0.48) | MEN1KMT2AACP3ADRA1DALDH1A1 | |
| SCHEMBL28302075 | 0.78 | BRD4 (0.55) | BRD4HDAC4HDAC7HDAC5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180345-A1 | THIENO- AND FURO[2,3-D]PYRIMIDINE-2,4[1H,3H]-DIONE DERIVATIVES AS TRPC5 MODULATORS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | Hydra Biosciences, Inc. (US) | 2017-06-21 | — | — | EP | disclosed |
| WO-2016023832-A1 | THIENO- AND FURO[2,3-D]PYRIMIDINE-2,4[1H,3H]-DIONE DERIVATIVES AS TRPC5 MODULATORS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | HYDRA BIOSCIENCES, INC. (US) | 2016-02-18 | — | — | WO | disclosed |