SCHEMBL22917154

SCHEMBL22917154

CC(=O)C(c1cccc(Cl)c1)c1cccc(Cl)c1

nearest known ligand 0.49

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ACP3 P15309 1/20 0.47
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
PARP1 P09874 1/20 0.42
ADRA1D P25100 1/20 0.42
ALDH1A1 P00352 2/20 0.42
HPGD P15428 2/20 0.42
TRPM8 Q7Z2W7 1/20 0.41
BRD4 O60885 1/20 0.41
LMNA P02545 1/20 0.41
MAPT P10636 1/20 0.41
HTT P42858 1/20 0.41
TSHR P16473 1/20 0.40
ALOX15 P16050 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22917201 0.94 MEN1 (0.53) ACP3MEN1KMT2AALDH1A1HPGD
SCHEMBL17504249 0.93 BRD4 (0.49) ACP3MEN1KMT2AADRA1DALDH1A1
SCHEMBL22917146 0.91 TRPM8 (0.44) ACP3MEN1KMT2ATRPM8LMNA
SCHEMBL22917155 0.90 HDAC4 (0.53) ACP3MEN1KMT2A
SCHEMBL12495860 0.85 ALDH1A1 (0.48) ACP3MEN1KMT2AADRA1DALDH1A1
SCHEMBL6628518 0.82 ACP3 (0.46) ACP3MEN1KMT2APARP1ADRA1D
SCHEMBL15695557 0.82 PTGS1 (0.46) ACP3MEN1KMT2AADRA1DALDH1A1
SCHEMBL12907075 0.82 ACP3 (0.46) ACP3MEN1KMT2APARP1ADRA1D
SCHEMBL12658713 0.82 ACP3 (0.46) ACP3MEN1KMT2APARP1ADRA1D
SCHEMBL11000344 0.82 MEN1 (0.54) ACP3MEN1KMT2APARP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3770148-A1 RECEPTOR INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF Beijing Tide Pharmaceutical Co., Ltd. (CN) 2021-01-27 EP disclosed