Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | ACVR2A | P27037 | 4/20 | 0.42 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 3/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19153690 | 0.81 | ERN1 (0.44) | IDO1DYRK1AACVR2ATGFBR2CYP19A1 | |
| SCHEMBL744054 | 0.79 | IDO1 (0.50) | IDO1DYRK1AACVR2ATGFBR2CYP19A1 | |
| SCHEMBL17376184 | 0.78 | ACVR2A (0.49) | IDO1DYRK1AACVR2ATGFBR2TGFBR1 | |
| SCHEMBL19127090 | 0.77 | ERN1 (0.57) | ERN1XDH | |
| SCHEMBL22283951 | 0.76 | IDO1 (0.48) | IDO1DYRK1AACVR2ATGFBR2CYP19A1 | |
| SCHEMBL30042559 | 0.76 | IDO1 (0.48) | IDO1DYRK1AACVR2ATGFBR2CYP19A1 | |
| SCHEMBL17503147 | 0.76 | ERN1 (0.51) | DYRK1AERN1PDE3BPDE3ACNR1 | |
| SCHEMBL1264943 | 0.75 | DYRK1A (0.45) | IDO1DYRK1AACVR2ATGFBR2CYP19A1 | |
| SCHEMBL30626327 | 0.74 | LOX (0.55) | IDO1DYRK1AACVR2ATGFBR2CYP19A1 | |
| SCHEMBL16116782 | 0.74 | LOX (0.55) | IDO1DYRK1AACVR2ATGFBR2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10654878-B2 | Compounds of phosphinanes and azaphosphinanes, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2020-05-19 | — | — | US | disclosed |
| US-20190031693-A1 | COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2019-01-31 | — | — | US | disclosed |
| US-20180016288-A1 | COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2018-01-18 | — | — | US | disclosed |
| US-20180016288-A1 | COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2018-01-18 | — | — | US | disclosed |
| WO-2017121969-A1 | NOVEL PHOSPHINANE AND AZAPHOSPHINANE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2017-07-20 | — | — | WO | disclosed |
| EP-3177614-A1 | [7,6]-FUSED BICYCLIC ANTIDIABETIC COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2017-06-14 | — | — | EP | disclosed |
| WO-2016019863-A1 | [7,6]-FUSED BICYCLIC ANTIDIABETIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10654878-B2 | Compounds of phosphinanes and azaphosphinanes, a process for their preparation and pharmaceutical compositions containing them | TK1, AK1, PHKA1 | IDO1 2059/4885DYRK1A 1276/4885ACVR2A 2316/4885 |
| US-20180016288-A1 | COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TK1, AK1, PHKA1 | IDO1 2059/4885DYRK1A 1276/4885ACVR2A 2316/4885 |
| US-20190031693-A1 | COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AK1, TK1, PHKA1 | IDO1 2162/4885DYRK1A 1249/4885ACVR2A 2398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.