Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.47 |
| ▸ | DAO | P14920 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067573 | 0.81 | GRIN1 (0.53) | DAOKDM4EMAPTHPGDSRD5A2 | |
| SCHEMBL24690029 | 0.79 | DAO (0.44) | PIN1DAOKDM4EMAPTHPGD | |
| SCHEMBL17505244 | 0.79 | DYRK1A (0.44) | DAOKDM4EMAPTHPGDSRD5A2 | |
| SCHEMBL17505227 | 0.79 | KDM4E (0.47) | PIN1DAOKDM4EMAPTHPGD | |
| SCHEMBL27352224 | 0.79 | IDO1 (0.44) | PIN1DAOKDM4EMAPTHPGD | |
| SCHEMBL5474613 | 0.74 | DAO (0.45) | PIN1DAOKDM4EMAPTHPGD | |
| SCHEMBL7922369 | 0.74 | CYP1A2 (0.41) | PIN1KDM4EMAPTHPGD | |
| SCHEMBL29377586 | 0.74 | CYP1A2 (0.41) | PIN1KDM4EMAPTHPGD | |
| SCHEMBL13625358 | 0.72 | PIN1 (0.51) | PIN1DAOKDM4EMAPTHPGD | |
| SCHEMBL1203267 | 0.70 | HRH4 (0.57) | DAOKDM4EMAPTHPGDSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260022131-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2026-01-22 | — | — | US | disclosed |
| US-12473302-B2 | 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-11-18 | — | — | US | disclosed |
| US-20240287092-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2024-08-29 | — | — | US | disclosed |
| US-11919913-B2 | 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2024-03-05 | — | — | US | disclosed |
| US-20210363155-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-11-25 | — | — | US | disclosed |
| US-11028098-B2 | 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-06-08 | — | — | US | disclosed |
| EP-3495357-B1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | UNIV COLUMBIA (US) | 2021-05-05 | — | — | EP | disclosed |
| EP-3495357-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | The Trustees of Columbia University in the City of New York (US) | 2019-06-12 | — | — | EP | disclosed |
| US-10273243-B2 | 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-04-30 | — | — | US | disclosed |
| US-20190031681-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-01-31 | — | — | US | disclosed |
| EP-2968304-B1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | UNIV COLUMBIA (US) | 2018-10-10 | — | — | EP | disclosed |
| US-20160046648-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10273243-B2 | 4-phenylpiperidines, their preparation and use | HTR3C, HRH4, CYP4F3 | PIN1 1053/4885DAO 3279/4885KDM4E 1332/4885 |
| US-20240287092-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HTR3C, HRH4, DRD3 | PIN1 1106/4885DAO 3228/4885KDM4E 1319/4885 |
| US-12473302-B2 | 4-phenylpiperidines, their preparation and use | HTR3C, HRH4, DRD3 | PIN1 1106/4885DAO 3228/4885KDM4E 1319/4885 |
| US-11919913-B2 | 4-phenylpiperidines, their preparation and use | HTR3C, HRH4, CYP4F3 | PIN1 1029/4885DAO 3213/4885KDM4E 1279/4885 |
| US-20210363155-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HTR3C, HRH4, CYP4F3 | PIN1 1029/4885DAO 3213/4885KDM4E 1279/4885 |
| US-20160046648-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HTR3C, HRH4, CYP4F3 | PIN1 1053/4885DAO 3279/4885KDM4E 1332/4885 |
| US-11028098-B2 | 4-phenylpiperidines, their preparation and use | HTR3C, HRH4, CYP4F3 | PIN1 972/4885DAO 3142/4885KDM4E 1343/4885 |
| US-20190031681-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HTR3C, HRH4, CYP4F3 | PIN1 972/4885DAO 3142/4885KDM4E 1343/4885 |
| US-20260022131-A1 | 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | CLN6, NR2E3, CBR3 | PIN1 4765/4885DAO 2773/4885KDM4E 3025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.