SCHEMBL1750858

SCHEMBL1750858

COC(=O)C1(CC#N)CCCCC1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 1/20 0.49
CYP4A11 Q02928 1/20 0.49
NPSR1 Q6W5P4 1/20 0.40
MAPT P10636 2/20 0.35
P2RX7 Q99572 1/20 0.34
CYP2C19 P33261 1/20 0.34
MEN1 O00255 1/20 0.34
CYP3A4 P08684 1/20 0.34
KMT2A Q03164 1/20 0.34
ALDH1A1 P00352 2/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CTSK P43235 1/20 0.33
CTSL P07711 3/20 0.32
CTSB P07858 3/20 0.32
CTSS P25774 2/20 0.32
DPP4 P27487 2/20 0.32
KDM4E B2RXH2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6626687 0.98 CYP4F2 (0.50) CYP4F2CYP4A11NPSR1MAPTP2RX7
SCHEMBL21772022 0.94 CYP4F2 (0.46) CYP4F2CYP4A11NPSR1P2RX7DPP4
SCHEMBL25281621 0.90 CYP4F2 (0.44) CYP4F2CYP4A11NPSR1
SCHEMBL14217137 0.82 OPRM1 (0.36) CYP4F2CYP4A11NPSR1KMT2ACTSL
SCHEMBL609248 0.81 CYP4F2 (0.49) CYP4F2CYP4A11NPSR1MAPTP2RX7
SCHEMBL609232 0.79 CYP4F2 (0.50) CYP4F2CYP4A11NPSR1MAPTP2RX7
SCHEMBL10535707 0.79 CYP4F2 (0.53) CYP4F2CYP4A11NPSR1MAPTP2RX7
SCHEMBL15437385 0.78 JAK2 (0.34) CYP4F2CYP4A11CYP2C19MEN1CYP3A4
SCHEMBL6632281 0.77 CYP4F2 (0.61) CYP4F2CYP4A11NPSR1P2RX7DPP4
SCHEMBL16699602 0.76 SMN1; SMN2 (0.39) MEN1KMT2AALDH1A1L3MBTL1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11591328-B2 Highly active CSF1R inhibitor compound XIAMEN BIOTIME BIOTECHNOLOGY CO., LTD. (CN) 2023-02-28 US disclosed
US-20200399265-A1 HIGHLY ACTIVE CSF1R INHIBITOR COMPOUND ADLAI NORTYE BIOPHARMA CO., LTD. (CN) 2020-12-24 US disclosed
EP-3744718-A1 HIGHLY ACTIVE CSF1R INHIBITOR COMPOUND Adlai Nortye Biopharma Co., Ltd. (CN) 2020-12-02 EP disclosed
WO-2019228252-A1 HIGHLY ACTIVE CSF1R INHIBITOR COMPOUND 杭州阿诺生物医药科技有限公司 (CN) 2019-12-05 WO disclosed
US-7968585-B2 Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 ELI LILLY AND COMPANY (US) 2011-06-28 US disclosed
US-7968585-B2 Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 ELI LILLY AND COMPANY (US) 2011-06-28 US disclosed
US-7968585-B2 Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 ELI LILLY AND COMPANY (US) 2011-06-28 US disclosed
EP-2035379-B1 INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 LILLY CO ELI (US) 2010-06-16 EP disclosed
EP-2035379-B1 INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 LILLY CO ELI (US) 2010-06-16 EP disclosed
US-20090099180-A1 INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY 2009-04-16 US disclosed
US-20090099180-A1 INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY 2009-04-16 US disclosed
US-20090099180-A1 INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY 2009-04-16 US disclosed
EP-2035379-A2 INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 Eli Lilly & Company (US) 2009-03-18 EP disclosed
WO-2007127763-A2 INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY (US) 2007-11-08 WO disclosed
WO-2007127763-A2 INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY (US) 2007-11-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11591328-B2 Highly active CSF1R inhibitor compound CSF1R, CSF3R, CD209 CYP4F2 3209/4885CYP4A11 3440/4885NPSR1 152/4885
US-20090099180-A1 INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 HSD11B1, HSD11B2, HSD3B1 CYP4F2 545/4885CYP4A11 18/4885NPSR1 1093/4885
US-20200399265-A1 HIGHLY ACTIVE CSF1R INHIBITOR COMPOUND CSF1R, CSF3R, CD209 CYP4F2 3209/4885CYP4A11 3440/4885NPSR1 152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.