Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | MME | P08473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL609232 | 0.98 | CYP4F2 (0.50) | CYP4F2CYP4A11NPSR1MEN1KMT2A | |
| SCHEMBL1750858 | 0.81 | CYP4F2 (0.49) | CYP4F2CYP4A11NPSR1MEN1KMT2A | |
| SCHEMBL6626687 | 0.79 | CYP4F2 (0.50) | CYP4F2CYP4A11NPSR1MEN1KMT2A | |
| SCHEMBL10535707 | 0.79 | CYP4F2 (0.53) | CYP4F2CYP4A11NPSR1MEN1KMT2A | |
| SCHEMBL5480927 | 0.76 | SMN1; SMN2 (0.39) | MEN1KMT2APOLBALDH1A1L3MBTL1 | |
| SCHEMBL11377781 | 0.76 | CYP2C19 (0.54) | MEN1KMT2APOLBCYP2C19ALDH1A1 | |
| SCHEMBL17857 | 0.76 | CYP4F2 (0.55) | CYP4F2CYP4A11NPSR1MEN1KMT2A | |
| SCHEMBL8270187 | 0.76 | CYP4F2 (0.59) | CYP4F2CYP4A11NPSR1MEN1KMT2A | |
| SCHEMBL612527 | 0.76 | ABCB11 (0.30) | CYP3A4 | |
| SCHEMBL21772022 | 0.76 | CYP4F2 (0.46) | CYP4F2CYP4A11NPSR1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557828-B2 | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBVIE INC. (US) | 2013-10-15 | — | — | US | disclosed |
| EP-2500347-A1 | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | Abbott Laboratories (US) | 2012-09-19 | — | — | EP | disclosed |
| EP-2142552-B1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LAB (US) | 2012-08-01 | — | — | EP | disclosed |
| US-20120041003-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | US | disclosed |
| US-8076344-B2 | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBOTT LABORATORIES (US) | 2011-12-13 | — | — | US | disclosed |
| EP-2142552-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2010-01-13 | — | — | EP | disclosed |
| US-20080293713-A1 | Inhibitors of Diacylglycerol O-acyltransferase Type 1 Enzyme | ABBOTT LABORATORIES (US) | 2008-11-27 | — | — | US | disclosed |
| WO-2008134690-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041003-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | DGAT1, DGAT2, LCAT | CYP4F2 1460/4885CYP4A11 1677/4885NPSR1 3575/4885 |
| US-20080293713-A1 | Inhibitors of Diacylglycerol O-acyltransferase Type 1 Enzyme | DGAT1, DGAT2, LCAT | CYP4F2 1460/4885CYP4A11 1677/4885NPSR1 3575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.