Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 17/20 | 0.49 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.41 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17509559 | 0.91 | TRPC5 (0.41) | TRPC5GRIN1GRIN2B | |
| SCHEMBL17509047 | 0.89 | TRPC5 (0.61) | TRPC5TRPC1TRPC4 | |
| SCHEMBL18061316 | 0.84 | TRPC5 (0.54) | TRPC5TRPC1TRPC4 | |
| SCHEMBL17509570 | 0.81 | TRPC5 (0.40) | TRPC5LMNA | |
| SCHEMBL17509082 | 0.80 | TRPC5 (0.51) | TRPC5TRPC1TRPC4GRIN1GRIN2B | |
| SCHEMBL18061310 | 0.79 | TRPC5 (0.51) | TRPC5TRPC1TRPC4 | |
| SCHEMBL17509549 | 0.78 | TRPC5 (0.44) | TRPC5GRIN1GRIN2B | |
| SCHEMBL18061318 | 0.78 | TRPC5 (0.51) | TRPC5TRPC1TRPC4 | |
| SCHEMBL17509563 | 0.77 | TRPC5 (0.60) | TRPC5TRPC1TRPC4 | |
| SCHEMBL17538697 | 0.77 | TRPC5 (0.41) | TRPC5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180340-B1 | PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE DERIVATIVES | HYDRA BIOSCIENCES INC (US) | 2018-10-10 | — | — | EP | disclosed |
| US-9440972-B2 | Pyrido[2,3-d]pyrimidine-2,4(1 H,3H)-dione derivatives | HYDRA BIOSCIENCES, INC. (US) | 2016-09-13 | — | — | US | disclosed |
| US-9440972-B2 | Pyrido[2,3-d]pyrimidine-2,4(1 H,3H)-dione derivatives | HYDRA BIOSCIENCES, INC. (US) | 2016-09-13 | — | — | US | disclosed |
| US-9440972-B2 | Pyrido[2,3-d]pyrimidine-2,4(1 H,3H)-dione derivatives | HYDRA BIOSCIENCES, INC. (US) | 2016-09-13 | — | — | US | disclosed |
| WO-2016023830-A1 | PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE DERIVATIVES | HYDRA BIOSCIENCES, INC. (US) | 2016-02-18 | — | — | WO | disclosed |
| US-20160046624-A1 | PYRIDO[2,3-d]PYRIMIDINE-2,4(1H,3H)-DIONE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046624-A1 | PYRIDO[2,3-d]PYRIMIDINE-2,4(1H,3H)-DIONE DERIVATIVES | TRPC5, P2RX5, HTR5A | TRPC5 1/4885TRPC1 13/4885TRPC4 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.