Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL955 | 0.87 | — | — | |
| Pyridine SCHEMBL28112986 | 0.85 | TSHR (0.45) | NOS1KDM4EALDH1A1 | |
| Bromide SCHEMBL18613940 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL5967566 | 0.84 | — | — | |
| Ethane SCHEMBL27569950 | 0.81 | — | — | |
| Trimethylammonium SCHEMBL27926119 | 0.77 | NOS1 (0.34) | NOS1 | |
| Methanesulfonamide SCHEMBL6305915 | 0.71 | CA1 (0.36) | NOS1 | |
| Pyrimidine SCHEMBL28763828 | 0.70 | TSHR (0.30) | — | |
| Pyrimidine SCHEMBL28567315 | 0.70 | TSHR (0.30) | — | |
| Pyrimidine SCHEMBL15778016 | 0.70 | NOS1 (0.33) | NOS1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220214355-A1 | SULFUR-HETEROCYCLE EXCHANGE CHEMISTRY AND USES THEREOF | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2022-07-07 | — | — | US | disclosed |
| CN-113853372-A | Thio-heterocyclic exchange chemistry and uses thereof | 弗吉尼亚大学专利基金委员会 | 2021-12-28 | — | — | CN | disclosed |
| EP-3924348-A2 | SULFUR-HETEROCYCLE EXCHANGE CHEMISTRY AND USES THEREOF | University of Virginia Patent Foundation (US) | 2021-12-22 | — | — | EP | disclosed |
| WO-2020214336-A9 | SULFUR-HETEROCYCLE EXCHANGE CHEMISTRY AND USES THEREOF | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2020-11-19 | — | — | WO | disclosed |
| WO-2020214336-A2 | SULFUR-HETEROCYCLE EXCHANGE CHEMISTRY AND USES THEREOF | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2020-10-22 | — | — | WO | disclosed |
| WO-2016022839-A1 | MODULATORS OF IRE1 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220214355-A1 | SULFUR-HETEROCYCLE EXCHANGE CHEMISTRY AND USES THEREOF | TST, TPST2, SRMS | NOS1 3163/4885KDM4E 1916/4885ALDH1A1 3058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.