Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.40 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19652287 | 0.90 | ADRA1A (0.50) | ALDH1A1MEN1KMT2ACYP3A4CYP2C19 | |
| SCHEMBL18267300 | 0.90 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2ACYP3A4CYP2C19 | |
| SCHEMBL25604665 | 0.90 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2ACYP3A4CYP2C19 | |
| SCHEMBL12449153 | 0.82 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AGAACHRNB2 | |
| SCHEMBL13615983 | 0.82 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AGAACHRNB2 | |
| SCHEMBL25107536 | 0.82 | MEN1 (0.46) | ALDH1A1MEN1KMT2ACYP3A4CYP2C19 | |
| SCHEMBL5020025 | 0.82 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AGAACHRNB2 | |
| SCHEMBL2606047 | 0.82 | ALDH1A1 (0.70) | ALDH1A1MEN1KMT2AGAACHRNB2 | |
| SCHEMBL13207242 | 0.81 | KDM4E (0.42) | ALDH1A1MEN1KMT2AADRA1AKDM4E | |
| SCHEMBL25630791 | 0.81 | CHRM1 (0.41) | ALDH1A1MEN1KMT2ACYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809545-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| US-20160046581-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046581-A1 | Factor XIa Inhibitors | F11, F12, TFPI | ALDH1A1 2920/4885MEN1 1105/4885KMT2A 3115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.