Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | QDPR | P09417 | 2/20 | 0.49 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17516279 | 0.84 | PDE4B (0.53) | SLC18A3PDE4BFAAHNPC1RAB9A | |
| SCHEMBL16144647 | 0.84 | ALDH1A1 (0.50) | SLC18A3PDE4BFAAHNPC1RAB9A | |
| SCHEMBL21714255 | 0.81 | SLC18A3 (0.55) | SLC18A3QDPRFAAHNPC1RAB9A | |
| SCHEMBL15300933 | 0.81 | KDM1A (0.53) | PDE4BQDPRNPC1RAB9ATP53 | |
| SCHEMBL1197270 | 0.81 | RAB9A (0.63) | NPC1RAB9ATP53SMN1; SMN2TSHR | |
| SCHEMBL19493962 | 0.81 | RAB9A (0.63) | NPC1RAB9ATP53SMN1; SMN2TSHR | |
| SCHEMBL26772714 | 0.79 | RAB9A (0.54) | PDE4BQDPRNPC1RAB9ATP53 | |
| SCHEMBL20805979 | 0.79 | ALDH1A1 (0.61) | PDE4BQDPRNPC1RAB9ALMNA | |
| SCHEMBL14276847 | 0.78 | HSD11B1 (0.56) | PDE4BQDPRNPC1RAB9ATP53 | |
| SCHEMBL17518892 | 0.76 | SLC18A3 (0.51) | SLC18A3QDPRTSHRALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809545-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| EP-2978425-B1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME (US) | 2017-09-27 | — | — | EP | disclosed |
| US-20160046581-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046581-A1 | Factor XIa Inhibitors | F11, F12, TFPI | SLC18A3 4869/4885PDE4B 2528/4885QDPR 4496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.