Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 4/20 | 0.64 |
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | CASP1 | P29466 | 3/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.64 |
| ▸ | USP2 | O75604 | 2/20 | 0.64 |
| ▸ | CASP7 | P55210 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4338667 | 0.88 | MEN1 (0.62) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL4323896 | 0.88 | MEN1 (0.70) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL4426664 | 0.86 | GRK6 (0.72) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL30628032 | 0.85 | MEN1 (0.78) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL4323748 | 0.85 | MEN1 (0.78) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL28644827 | 0.85 | POLB (0.73) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL30628022 | 0.85 | POLB (0.73) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL4325072 | 0.85 | MEN1 (0.79) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL4323764 | 0.84 | MEN1 (0.57) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL4319306 | 0.84 | MEN1 (0.59) | MEN1KMT2AMAPTNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050154015-A1 | Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2005-07-14 | — | — | US | claimed |
| EP-1230232-B1 | SUBSTITUTED 4H-CHROMENE AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA INC (US) | 2004-02-25 | — | — | EP | claimed |
| US-7968595-B2 | R-stereoisomer of 2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-3-cyano-4H-chromene; treating solid tumors and ocular neovascularization; combination therapy; prodrugs made by reacting with protected amino acid | CYTOVIA, INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-7968595-B2 | R-stereoisomer of 2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-3-cyano-4H-chromene; treating solid tumors and ocular neovascularization; combination therapy; prodrugs made by reacting with protected amino acid | CYTOVIA, INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-7968595-B2 | R-stereoisomer of 2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-3-cyano-4H-chromene; treating solid tumors and ocular neovascularization; combination therapy; prodrugs made by reacting with protected amino acid | CYTOVIA, INC. (US) | 2011-06-28 | — | — | US | disclosed |
| EP-2049101-A2 | SUBSTITUTED 4-ARYL-CHROMENE AS ACTIVATOR OF CASPASES AND INDUCER OF APOPTOSIS AND AS ANTIVASCULAR AGENT AND THE USE THEREOF | Cytovia, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| US-7507762-B2 | Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2009-03-24 | — | — | US | disclosed |
| US-20080085328-A1 | Substituted 4-aryl-chromene as activator of caspases and inducer of apoptosis and as antivascular agent and the use thereof | DISCOVER GROWTH FUND, LLC (VI) | 2008-04-10 | — | — | US | disclosed |
| US-20080085328-A1 | Substituted 4-aryl-chromene as activator of caspases and inducer of apoptosis and as antivascular agent and the use thereof | DISCOVER GROWTH FUND, LLC (VI) | 2008-04-10 | — | — | US | disclosed |
| US-20080085328-A1 | Substituted 4-aryl-chromene as activator of caspases and inducer of apoptosis and as antivascular agent and the use thereof | DISCOVER GROWTH FUND, LLC (VI) | 2008-04-10 | — | — | US | disclosed |
| WO-2008005572-A2 | SUBSTITUTED 4-ARYL-CHROMENE AS ACTIVATOR OF CASPASES AND INDUCER OF APOPTOSIS AND AS ANTIVASCULAR AGENT AND THE USE THEREOF | CYTOVIA, INC. (US) | 2008-01-10 | — | — | WO | disclosed |
| US-20050154015-A1 | Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2005-07-14 | — | — | US | disclosed |
| US-6906203-B1 | Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2005-06-14 | — | — | US | disclosed |
| EP-1230232-B1 | SUBSTITUTED 4H-CHROMENE AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA INC (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1230232-A2 | SUBSTITUTED 4H-CHROMENE AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | Cytovia, Inc. (US) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001034591-A2 | SUBSTITUTED 4H-CHROMENE AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2001-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050154015-A1 | Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP4, CASP3, CASP5 | MEN1 2868/4885KMT2A 3138/4885MAPT 4779/4885 |
| US-20080085328-A1 | Substituted 4-aryl-chromene as activator of caspases and inducer of apoptosis and as antivascular agent and the use thereof | CASP1, CASP2, CASP3 | MEN1 2169/4885KMT2A 3460/4885MAPT 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.