Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1752484 | 0.79 | LTA4H (0.55) | ALDH1A1KDM4EGAAMAPTLMNA | |
| SCHEMBL1752163 | 0.75 | CYP2D6 (0.50) | ALDH1A1KDM4EMAPTLMNAKMT2A | |
| SCHEMBL1751870 | 0.71 | MAPT (0.42) | ALDH1A1GAAMAPTKCNJ1KCNH2 | |
| SCHEMBL10360277 | 0.70 | KCNJ1 (0.69) | ALDH1A1GAAMAPTLMNAKCNJ1 | |
| SCHEMBL1752221 | 0.70 | DRD2 (0.50) | ALDH1A1KDM4EMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL9396792 | 0.67 | GAA (0.84) | ALDH1A1KDM4EGAAMAPTLMNA | |
| SCHEMBL7517180 | 0.67 | GAA (0.84) | ALDH1A1KDM4EGAAMAPTLMNA | |
| SCHEMBL27961047 | 0.67 | CYP1A2 (0.68) | ALDH1A1KDM4EGAAMAPTLMNA | |
| SCHEMBL27997065 | 0.67 | GAA (0.67) | ALDH1A1KDM4EGAAMAPTLMNA | |
| SCHEMBL27734023 | 0.66 | KCNJ1 (0.63) | ALDH1A1KDM4EMAPTLMNAKCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900735-B1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | INST PHARM & TOXICOLOGY AMMS (CN) | 2012-06-13 | — | — | EP | claimed |
| US-20110059978-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | LI SONG | 2011-03-10 | — | — | US | claimed |
| US-20080269232-A1 | Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2008-10-30 | — | — | US | claimed |
| EP-1900735-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2008-03-19 | — | — | EP | claimed |
| US-8410105-B2 | Pyridazinyl amine derivatives, the use thereof in the preparation of picorna virus inhibitors | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2013-04-02 | — | — | US | disclosed |
| EP-1900735-B1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | INST PHARM & TOXICOLOGY AMMS (CN) | 2012-06-13 | — | — | EP | disclosed |
| US-8076339-B2 | Pyridazine compound; also useful against rhinovirus | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China of Beijing (CN) | 2011-12-13 | — | — | US | disclosed |
| US-20110059978-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | LI SONG | 2011-03-10 | — | — | US | disclosed |
| US-20080269232-A1 | Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2008-10-30 | — | — | US | disclosed |
| EP-1900735-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2008-03-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059978-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | RNASEH1, PIR, HAVCR2 | ALDH1A1 2140/4885KDM4E 1857/4885GAA 2352/4885 |
| US-20080269232-A1 | Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors | RNASEH1, PIR, HAVCR2 | ALDH1A1 2140/4885KDM4E 1857/4885GAA 2352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.