Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27660970 | 0.85 | KCNJ1 (0.40) | MAPTKCNJ1KCNH2ALDH1A1ACHE | |
| SCHEMBL14790114 | 0.76 | KCNJ1 (0.53) | MAPTKCNJ1KCNH2ALDH1A1HRH3 | |
| SCHEMBL1751930 | 0.73 | TYMP (0.40) | MAPTACHE | |
| SCHEMBL14785737 | 0.72 | KCNJ1 (0.72) | KCNJ1KCNH2HRH3MAOASIGMAR1 | |
| SCHEMBL1752484 | 0.71 | LTA4H (0.55) | MAPTGAAALDH1A1HRH3 | |
| SCHEMBL1751997 | 0.71 | ALDH1A1 (0.47) | MAPTGAAKCNJ1KCNH2ALDH1A1 | |
| SCHEMBL15954217 | 0.70 | HTT (0.54) | MAPTKCNJ1KCNH2ALDH1A1HRH3 | |
| SCHEMBL18280033 | 0.70 | ALDH1A1 (0.51) | MAPTGAAALDH1A1ACHEMAOA | |
| SCHEMBL15964106 | 0.68 | KCNJ1 (0.56) | KCNJ1KCNH2HRH3MAOA | |
| SCHEMBL14782744 | 0.68 | ALDH1A1 (0.60) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900735-B1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | INST PHARM & TOXICOLOGY AMMS (CN) | 2012-06-13 | — | — | EP | claimed |
| US-8076339-B2 | Pyridazine compound; also useful against rhinovirus | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China of Beijing (CN) | 2011-12-13 | — | — | US | claimed |
| US-20080269232-A1 | Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2008-10-30 | — | — | US | claimed |
| EP-1900735-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2008-03-19 | — | — | EP | claimed |
| US-8410105-B2 | Pyridazinyl amine derivatives, the use thereof in the preparation of picorna virus inhibitors | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2013-04-02 | — | — | US | disclosed |
| EP-1900735-B1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | INST PHARM & TOXICOLOGY AMMS (CN) | 2012-06-13 | — | — | EP | disclosed |
| US-8076339-B2 | Pyridazine compound; also useful against rhinovirus | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China of Beijing (CN) | 2011-12-13 | — | — | US | disclosed |
| US-20110059978-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | LI SONG | 2011-03-10 | — | — | US | disclosed |
| US-20080269232-A1 | Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2008-10-30 | — | — | US | disclosed |
| EP-1900735-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2008-03-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059978-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | RNASEH1, PIR, HAVCR2 | MAPT 829/4885GAA 2352/4885KCNJ1 1389/4885 |
| US-20080269232-A1 | Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors | RNASEH1, PIR, HAVCR2 | MAPT 829/4885GAA 2352/4885KCNJ1 1389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.