Sugi Predict

Sugi Predict / Compounds / SCHEMBL17522189

SCHEMBL17522189

SCHEMBL17522189

C=CC(=O)Nc1c(F)cccc1NC(C)C

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.44
▸ FGFR4 P22455 4/20 0.41
▸ FGFR1 P11362 3/20 0.41
▸ FGFR2 P21802 1/20 0.41
▸ FGFR3 P22607 1/20 0.41
▸ TGM2 P21980 4/20 0.41
▸ BRD4 O60885 1/20 0.40
▸ KDR P35968 1/20 0.40
▸ EPHB4 P54760 1/20 0.40
▸ TEK Q02763 1/20 0.40
▸ GSTO1 P78417 1/20 0.38
▸ LMNA P02545 2/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ MEN1 O00255 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ EGFR P00533 1/20 0.37
▸ TRPA1 O75762 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19363767 0.87 FGFR4 (0.41) ALDH1A1FGFR4FGFR1FGFR2FGFR3
SCHEMBL17524753 0.84 ALDH1A1 (0.47) ALDH1A1FGFR4FGFR1FGFR2FGFR3
SCHEMBL17522196 0.83 TGM2 (0.41) ALDH1A1FGFR1TGM2BRD4KDR
SCHEMBL4732340 0.81 ALDH1A1 (0.62) ALDH1A1TGM2BRD4KDREPHB4
SCHEMBL23652893 0.81 ALDH1A1 (0.47) ALDH1A1FGFR4FGFR1FGFR2FGFR3
SCHEMBL17522206 0.79 TGM2 (0.50) ALDH1A1TGM2GSTO1LMNASMN1; SMN2
SCHEMBL25249826 0.77 ALDH1A1 (0.50) ALDH1A1FGFR4FGFR1TGM2BRD4
SCHEMBL17522198 0.75 ALDH1A1 (0.43) ALDH1A1FGFR4FGFR1TGM2BRD4
SCHEMBL29410342 0.74 SMN1; SMN2 (0.55) ALDH1A1TGM2KDREPHB4TEK
SCHEMBL25294216 0.74 SMN1; SMN2 (0.55) ALDH1A1TGM2KDREPHB4TEK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10618902-B2 Substituted pyrido[2,3-d]pyrimidines as inhibitors of protein kinases CELGENE CAR LLC (BM) 2020-04-14 — — US disclosed
US-20190218220-A1 HETEROARYL COMPOUNDS AND USES THEREOF BRISTOL-MYERS SQUIBB COMPANY 2019-07-18 — — US disclosed
US-20170267685-A1 HETEROARYL COMPOUNDS AND USES THEREOF BRISTOL-MYERS SQUIBB COMPANY 2017-09-21 — — US disclosed
US-20170267685-A1 HETEROARYL COMPOUNDS AND USES THEREOF BRISTOL-MYERS SQUIBB COMPANY 2017-09-21 — — US disclosed
US-9663524-B2 Substituted pyrido[2,3-d]pyrimidines as protein kinase inhibitors CELGENE CAR LLC (BM) 2017-05-30 — — US disclosed
US-9663524-B2 Substituted pyrido[2,3-d]pyrimidines as protein kinase inhibitors CELGENE CAR LLC (BM) 2017-05-30 — — US disclosed
US-20160046634-A1 HETEROARYL COMPOUNDS AND USES THEREOF BRISTOL-MYERS SQUIBB COMPANY 2016-02-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190218220-A1 HETEROARYL COMPOUNDS AND USES THEREOF PRKACA, PRKDC, AURKC ALDH1A1 3719/4885FGFR4 1590/4885FGFR1 1733/4885
US-20170267685-A1 HETEROARYL COMPOUNDS AND USES THEREOF PRKACA, PRKDC, AURKC ALDH1A1 3719/4885FGFR4 1590/4885FGFR1 1733/4885
US-10618902-B2 Substituted pyrido[2,3-d]pyrimidines as inhibitors of protein kinases PDXK, DCK, DTYMK ALDH1A1 3786/4885FGFR4 1220/4885FGFR1 1156/4885
US-20160046634-A1 HETEROARYL COMPOUNDS AND USES THEREOF PRKACA, PRKDC, AURKC ALDH1A1 3719/4885FGFR4 1590/4885FGFR1 1733/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.