Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17524122 | 1.00 | ALDH1A1 (0.52) | ALDH1A1HPGDALOX5MAPTL3MBTL1 | |
| SCHEMBL19181028 | 0.86 | SMN1; SMN2 (0.54) | ALDH1A1HPGDALOX5MAPTL3MBTL1 | |
| SCHEMBL17506009 | 0.86 | SMN1; SMN2 (0.54) | ALDH1A1HPGDALOX5MAPTL3MBTL1 | |
| SCHEMBL19181332 | 0.86 | SMN1; SMN2 (0.54) | ALDH1A1HPGDALOX5MAPTL3MBTL1 | |
| SCHEMBL17506001 | 0.86 | SMN1; SMN2 (0.54) | ALDH1A1HPGDALOX5MAPTL3MBTL1 | |
| SCHEMBL17505998 | 0.84 | ALDH1A1 (0.47) | ALDH1A1HPGDALOX5MAPTL3MBTL1 | |
| SCHEMBL19182066 | 0.84 | ALDH1A1 (0.47) | ALDH1A1HPGDALOX5MAPTL3MBTL1 | |
| SCHEMBL19181382 | 0.84 | ALDH1A1 (0.47) | ALDH1A1HPGDALOX5MAPTL3MBTL1 | |
| SCHEMBL17506006 | 0.84 | ALDH1A1 (0.47) | ALDH1A1HPGDALOX5MAPTL3MBTL1 | |
| SCHEMBL19200767 | 0.82 | RAB9A (0.50) | ALDH1A1HPGDALOX5MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170217914-A1 | Novel Triarylethylene Compounds and Methods Using Same | THE PENN STATE RESEARCH FOUNDATION | 2017-08-03 | — | — | US | disclosed |
| WO-2016022325-A1 | NOVEL TRIARYLETHYLENE COMPOUNDS AND METHODS USING SAME | THE PENN STATE RESEARCH FOUNDATION (US) | 2016-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217914-A1 | Novel Triarylethylene Compounds and Methods Using Same | CYP46A1, GSTA2, GSTA1 | ALDH1A1 176/4885HPGD 533/4885ALOX5 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.