Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | G6PD | P11413 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MPI | P34949 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17525951 | 0.88 | CYP19A1 (0.53) | ESR1MAPTMEN1KMT2AESR2 | |
| SCHEMBL17525983 | 0.80 | MAPT (0.44) | ESR1MAPTMEN1KMT2AESR2 | |
| SCHEMBL29470239 | 0.79 | ESR1 (0.61) | ESR1MAPTMEN1KMT2AESR2 | |
| SCHEMBL14048666 | 0.78 | LMNA (0.56) | ESR1MAPTMEN1KMT2AESR2 | |
| SCHEMBL13952052 | 0.77 | STS (0.50) | ESR1MAPTMEN1KMT2AESR2 | |
| SCHEMBL13951889 | 0.76 | STS (0.69) | ESR1MAPTESR2LMNACYP3A4 | |
| SCHEMBL14048673 | 0.76 | SHBG (0.50) | ESR1MAPTMEN1KMT2AESR2 | |
| SCHEMBL13952055 | 0.75 | STS (0.61) | ESR1MAPTESR2LMNACYP3A4 | |
| SCHEMBL14048668 | 0.73 | STS (0.51) | ESR1MAPTMEN1KMT2AESR2 | |
| SCHEMBL8508439 | 0.73 | ESR1 (0.46) | ESR1MAPTMEN1KMT2AESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2147014-B1 | 17ALPHA-SUBSTITUTED STEROIDS AS SYSTEMIC ANTIANDROGENS AND SELECTIVE ANDROGEN RECEPTOR MODULATORS | ENDORECH INC (CA) | 2016-02-17 | — | — | EP | disclosed |