Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753530 | 0.83 | LIPG (0.40) | BACE1 | |
| SCHEMBL12474238 | 0.76 | BACE1 (0.39) | BACE1 | |
| SCHEMBL12112049 | 0.73 | CYP3A4 (0.33) | BACE1 | |
| SCHEMBL16001661 | 0.72 | BACE1 (0.34) | BACE1 | |
| SCHEMBL12365633 | 0.72 | LPL (0.43) | BACE1 | |
| SCHEMBL23436911 | 0.72 | LIPG (0.42) | BACE1 | |
| SCHEMBL20088877 | 0.71 | LIPG (0.45) | BACE1 | |
| SCHEMBL22501786 | 0.71 | CYP2C19 (0.40) | BACE1 | |
| SCHEMBL21001399 | 0.70 | BACE1 (0.37) | BACE1 | |
| SCHEMBL18979706 | 0.69 | BACE1 (0.36) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158041-A1 | Tyrosine Kinase Inhibitors | MERCK SHARP & DOHME CORP. | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158041-A1 | Tyrosine Kinase Inhibitors | MET, ABL1, ERBB2 | BACE1 4344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.