Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Cipepofol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 7/20 | 0.65 |
| ▸ | GABRB1 known ✓ | P18505 | 5/20 | 0.65 |
| ▸ | GABRB2 known ✓ | P47870 | 3/20 | 0.65 |
| ▸ | GABRG2 known ✓ | P18507 | 2/20 | 0.65 |
| ▸ | GABRB3 known ✓ | P28472 | 2/20 | 0.65 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.65 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.65 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.65 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.65 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.65 |
| ▸ | CA1 | P00915 | 2/20 | 0.65 |
| ▸ | CA2 | P00918 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.65 |
| ▸ | FAAH | O00519 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cipepofol SCHEMBL17515121 | 1.00 | GABRA1 (0.65) | GABRA1GABRB1GABRB2CYP1A2GABRG2 | |
| Cipepofol SCHEMBL30001127 | 1.00 | GABRA1 (0.65) | GABRA1GABRB1GABRB2CYP1A2GABRG2 | |
| Cipepofol SCHEMBL17537109 | 1.00 | GABRA1 (0.65) | GABRA1GABRB1GABRB2CYP1A2GABRG2 | |
| Cipepofol SCHEMBL17515120 | 1.00 | GABRA1 (0.65) | GABRA1GABRB1GABRB2CYP1A2GABRG2 | |
| SCHEMBL17565217 | 0.94 | GABRA1 (0.54) | GABRA1GABRB1GABRB2CYP1A2GABRG2 | |
| SCHEMBL17565218 | 0.94 | GABRA1 (0.54) | GABRA1GABRB1GABRB2CYP1A2GABRG2 | |
| SCHEMBL17537206 | 0.94 | GABRA1 (0.54) | GABRA1GABRB1GABRB2CYP1A2GABRG2 | |
| SCHEMBL17537205 | 0.94 | GABRA1 (0.54) | GABRA1GABRB1GABRB2CYP1A2GABRG2 | |
| SCHEMBL17537117 | 0.94 | GABRA1 (0.54) | GABRA1GABRB1GABRB2CYP1A2GABRG2 | |
| SCHEMBL17537082 | 0.94 | GABRA1 (0.54) | GABRA1GABRB1GABRB2CYP1A2GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113521038-A | Anesthetic pharmaceutical composition and application thereof | 海思科医药集团股份有限公司 | 2021-10-22 | — | — | CN | claimed |
| CN-113521038-B | Anesthetic pharmaceutical composition and application thereof | 西藏海思科制药有限公司 | 2025-08-01 | — | — | CN | disclosed |
| CN-118791364-A | Cycloparaffin intermediate and preparation method of cycloparaffin | 山东百诺医药股份有限公司 | 2024-10-18 | — | — | CN | disclosed |
| EP-3189834-B1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | HAISCO INNOVATIVE PHARMACEUTICAL PTE LTD (SG) | 2024-01-17 | — | — | EP | disclosed |
| CN-117091929-A | Method for rapidly extracting and detecting cycloparaffin from suspension or body fluid | 中国科学院大连化学物理研究所 | 2023-11-21 | — | — | CN | disclosed |
| CN-116829523-A | Phenol derivative, crystal form and preparation method thereof | 天地恒一制药股份有限公司 | 2023-09-29 | — | — | CN | disclosed |
| US-20230118143-A1 | PHARMACEUTICAL PREPARATION AND PREPARATION METHOD THEREFOR | XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2023-04-20 | — | — | US | disclosed |
| CN-113801004-A | Phenyl bisphenol derivative, preparation method and medical application thereof | 四川海思科制药有限公司 | 2021-12-17 | — | — | CN | disclosed |
| CN-109415285-B | Phenyl bisphenol derivative, preparation method and medical application thereof | 四川海思科制药有限公司 | 2021-12-14 | — | — | CN | disclosed |
| WO-2021239130-A1 | PHARMACEUTICAL PREPARATION AND PREPARATION METHOD THEREFOR | 四川海思科制药有限公司 | 2021-12-02 | — | — | WO | disclosed |
| WO-2016034079-A1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | 四川海思科制药有限公司 | 2016-03-10 | — | — | WO | disclosed |
| WO-2016034079-A1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | 四川海思科制药有限公司 | 2016-03-10 | — | — | WO | disclosed |
| CN-105384607-A | Isopropyl-phenol derivative and preparation method therefor | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |
| CN-105384604-A | Isopropyl-phenol derivative and preparation method therefor | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |
| CN-105384619-A | Isopropyl-phenol derivative and preparation method therefor | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |
| US-20160060197-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2016-03-03 | — | — | US | disclosed |
| US-20160060197-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2016-03-03 | — | — | US | disclosed |
| US-20160060197-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2016-03-03 | — | — | US | disclosed |
| WO-2016026459-A1 | ISOPROPYL PHENOL DERIVATIVE AND PREPARATION METHOD THEREOF | 四川海思科制药有限公司 | 2016-02-25 | — | — | WO | disclosed |
| CN-104507899-A | Phenol derivative, preparation method and medical application thereof | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2015-04-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060197-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | CYP2D6, CYP2B6, CYP2A6 | GABRA1 2665/4885GABRB1 3276/4885GABRB2 3304/4885 |
| US-20230118143-A1 | PHARMACEUTICAL PREPARATION AND PREPARATION METHOD THEREFOR | GABRA1, GABRR1, GABARAPL1 | GABRA1 1/4885GABRB1 5/4885GABRB2 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.