Sugi Predict

Sugi Predict / Compounds / SCHEMBL17533775

SCHEMBL17533775

SCHEMBL17533775

Clc1ccc(Cn2cc(Cc3nc4ccccc4[nH]3)nn2)c(Cl)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EGFR P00533 4/20 0.50
▸ ERBB2 P04626 3/20 0.50
▸ KCNMA1 Q12791 1/20 0.48
▸ CDC7 O00311 1/20 0.46
▸ GAA P10253 2/20 0.46
▸ MGAM O43451 1/20 0.46
▸ SI P14410 1/20 0.46
▸ MGAM2 Q2M2H8 1/20 0.46
▸ SLC9A1 P19634 1/20 0.46
▸ KDM4E B2RXH2 1/20 0.43
▸ LMNA P02545 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ PKM P14618 1/20 0.43
▸ MAPK1 P28482 1/20 0.43
▸ NPC1 O15118 3/20 0.42
▸ RAB9A P51151 3/20 0.42
▸ AMY1A P0DUB6 1/20 0.42
▸ DRD4 P21917 2/20 0.42
▸ POLB P06746 2/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19377847 0.83 GAA (0.53) EGFRERBB2KCNMA1GAAMGAM
SCHEMBL29810805 0.81 EGFR (0.59) EGFRERBB2GAAKDM4ELMNA
SCHEMBL2948135 0.81 EGFR (0.59) EGFRERBB2GAAKDM4ELMNA
SCHEMBL19377857 0.72 EGFR (0.46) EGFRERBB2KDM4ELMNAMAPT
SCHEMBL30956287 0.70 TDP1 (0.46) EGFRERBB2GAAKDM4ELMNA
SCHEMBL17513429 0.70 PTGS2 (0.54) KDM4ELMNAMAPTPKMNPC1
SCHEMBL19377886 0.69 EGFR (0.43) EGFRERBB2GAASLC9A1KDM4E
SCHEMBL17513534 0.69 EGLN1 (0.53) KCNMA1CDC7GAAMGAMSI
SCHEMBL12595107 0.69 HDAC3 (0.46) EGFRERBB2GAAKDM4EPKM
SCHEMBL19378046 0.69 IRAK4 (0.52) EGFRERBB2GAAKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170275279-A1 SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE UNIVERSITY OF WASHINGTON 2017-09-28 — — US claimed
US-10913736-B2 Specific inhibitors of methionyl-tRNA synthetase UNIVERSITY OF WASHINGTON (US) 2021-02-09 — — US disclosed
US-10913736-B2 Specific inhibitors of methionyl-tRNA synthetase UNIVERSITY OF WASHINGTON (US) 2021-02-09 — — US disclosed
US-20170275279-A1 SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE UNIVERSITY OF WASHINGTON 2017-09-28 — — US disclosed
US-20170275279-A1 SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE UNIVERSITY OF WASHINGTON 2017-09-28 — — US disclosed
US-20170275279-A1 SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE UNIVERSITY OF WASHINGTON 2017-09-28 — — US disclosed
WO-2016029146-A1 SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE UNIVERSITY OF WASHINGTON (US) 2016-02-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170275279-A1 SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE AARS1, MTR, GARS1 EGFR 3681/4885ERBB2 3193/4885KCNMA1 4736/4885
US-10913736-B2 Specific inhibitors of methionyl-tRNA synthetase AARS1, MTR, GARS1 EGFR 3681/4885ERBB2 3193/4885KCNMA1 4736/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.