Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 1/20 | 0.43 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ATP4A | P20648 | 1/20 | 0.42 |
| ▸ | ATP4B | P51164 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8694874 | 0.85 | CNR1 (0.41) | RHEB | |
| SCHEMBL17536018 | 0.83 | S1PR4 (0.52) | SMN1; SMN2RAB9AATP4AATP4BLIPE | |
| SCHEMBL2904391 | 0.83 | ATP4A (0.43) | SMN1; SMN2RAB9AHTTATP4AATP4B | |
| SCHEMBL2026551 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2HTTATP4AATP4BLIPE | |
| SCHEMBL8694664 | 0.81 | S1PR4 (0.51) | SMN1; SMN2RAB9AHTTATP4AATP4B | |
| Hydrochloric Acid SCHEMBL11833848 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2HTTATP4AATP4BLIPE | |
| SCHEMBL2435879 | 0.79 | L3MBTL1 (0.44) | SMN1; SMN2RAB9AHTTLIPEFOLH1 | |
| SCHEMBL24930498 | 0.78 | MPO (0.50) | SMN1; SMN2RAB9AHTTATP4AATP4B | |
| SCHEMBL22850860 | 0.78 | MAPT (0.43) | SMN1; SMN2RAB9AHTTFOLH1TDP1 | |
| SCHEMBL31394965 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9AHTTLIPEFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726315-A | Certain 3-hydroxy-6-hydroxymethyl-pyridine intermediates | SMITHKLINE BEECHAM PLC (GB) | 1998-03-10 | — | — | US | disclosed |
| US-5646286-A | Palladium catalyzed vinylic substitution reactions with 2-substituted-pyridines | SMITHKLINE BEECHAM PLC (GB) | 1997-07-08 | — | — | US | disclosed |
| EP-0705249-B1 | PALLADIUM CATALYZED VINYLIC SUBSTITUTION REACTIONS WITH 2-SUBSTITUTED-PYRIDINES | SMITHKLINE BEECHAM PLC (GB) | 1997-05-14 | — | — | EP | disclosed |
| EP-0705249-A1 | PALLADIUM CATALYZED VINYLIC SUBSTITUTION REACTIONS WITH 2-SUBSTITUTED-PYRIDINES | SMITHKLINE BEECHAM PLC (GB) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000487-A1 | PALLADIUM CATALYZED VINYLIC SUBSTITUTION REACTIONS WITH 2-SUBSTITUTED-PYRIDINES | SMITHKLINE BEECHAM PLC (GB) | 1995-01-05 | — | — | WO | disclosed |