Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165115 | 0.81 | TYMS (0.46) | TYMSLPAR3LPAR2LMNACYP3A4 | |
| SCHEMBL28377717 | 0.79 | LPAR3 (0.45) | TYMSLPAR3LPAR2LMNACYP3A4 | |
| SCHEMBL167243 | 0.79 | LPAR3 (0.45) | TYMSLPAR3LPAR2LMNACYP3A4 | |
| Zinc Ion SCHEMBL19253796 | 0.78 | CA1 (0.42) | BBOX1 | |
| SCHEMBL19253794 | 0.76 | FABP3 (0.44) | BBOX1 | |
| SCHEMBL10870322 | 0.76 | CA1 (0.46) | NFKB1 | |
| Zinc Ion SCHEMBL19253790 | 0.76 | FABP3 (0.44) | BBOX1 | |
| SCHEMBL9755639 | 0.76 | CA1 (0.46) | NFKB1 | |
| SCHEMBL19253792 | 0.76 | FABP3 (0.44) | BBOX1 | |
| SCHEMBL167095 | 0.74 | TYMS (0.48) | TYMSLPAR3LPAR2LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10092680-B2 | Metal medical device | SUMITOMO RUBBER INDUSTRIES, LTD. (JP) | 2018-10-09 | — | — | US | disclosed |
| US-20160058919-A1 | METAL MEDICAL DEVICE | SUMITOMO RUBBER INDUSTRIES, LTD. (JP) | 2016-03-03 | — | — | US | disclosed |